Commercial Production of Astaxanthin from the Green Alga Haematococcus pluvialis

Miyakawa, Kazuyuki

doi:10.1007/978-981-15-7360-6_1

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…Las funciones de la astaxantina incluyen protección retinal, recuperación de la astenopía, acondicionamiento de la piel, y mejora de la función cognitiva, resistencia a la insulina y sarcopenia (Miyakawa 2021). Por ejemplo, los carotenoides dietéticos amarillos, como la zeaxantina o el βcaroteno, pueden hidroxilarse o cetolarse en el cetocarotenoide rojo astaxantina, y la astaxantina (Fig.…”

Section: β-Caroteno Y Astaxantinaunclassified

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Carotenoides

Romero,

Espinoza

2024

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Con gran satisfacción y entusiasmo se presenta ante la comunidad científica, la presente obra, un libro dedicado a despejar las innumerables dudas respecto al conocimiento de las características, propiedades y métodos de extracción de carotenoides: carotenos y xantófilas. Este libro enfatiza en la importancia que tiene conocer acerca de la estructura, propiedades, biosíntesis, biodisponibilidad en el cuerpo humano, factores que afectan su biodisponibilidad y técnicas de extracción de los carotenoides es para conocer el fundamento de sus funciones esenciales tanto en las plantas como en el ser vivo, en plantas, captan la energía luminosa y actúan como antioxidantes. En el ser vivo al consumir los carotenoides se transforman en vitamina A, micronutriente que interviene en una amplia variedad de funciones fisiológicas, entre las que destaca la función visual, formación y mantenimiento de tejidos blandos, dientes, mucosas y piel, y tiene también un papel clave en el desarrollo fetal, embarazo y lactancia.

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Section: β-Caroteno Y Astaxantinaunclassified

“…140) (Hara et al, 2021). El contenido de astaxantina en H. pluvialis cultivado en estanques abiertos es normalmente 1.5-3% (sobre una base de forma libre) mientras que esto puede ser >4% usando un fotobiorreactor tubular, dependiendo de la temporada y el clima local (Miyakawa 2021).…”

Section: 𝑪𝑶 𝟐 Supercríticounclassified

Carotenoides

Romero,

Espinoza

2024

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“…Recently, the details of laboratory and commercial scale cultivation procedures in the production of natural astaxanthin derived from H. pluvialis have been discussed [42][43][44]. The effects of different cultivation conditions and strategies, technological innovations and types of cultivation systems and an economic assessment for astaxanthin production were also reviewed [45][46][47][48][49][50][51][52].…”

Section: Cultivation and Growth Stagesmentioning

confidence: 99%

Extraction of Valuable Biomolecules from the Microalga Haematococcus pluvialis Assisted by Electrotechnologies

et al. 2023

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The freshwater microalga Haematococcus pluvialis is well known as the cell factory for natural astaxanthin, which composes up to 4–7% of its total dry weight. The bioaccumulation of astaxanthin in H. pluvialis cysts seems to be a very complex process that depends on different stress conditions during its cultivation. The red cysts of H. pluvialis develop thick and rigid cell walls under stress growing conditions. Thus, the biomolecule extraction requires general cell disruption technologies to reach a high recovery rate. This short review provides an analysis of the different steps in H. pluvialis’s up and downstream processing including cultivation and harvesting of biomass, cell disruption, extraction and purification techniques. Useful information on the structure of H. pluvialis’s cells, biomolecular composition and properties and the bioactivity of astaxanthin is collected. Special emphasis is given to the recent progress in application of different electrotechnologies during the growth stages and for assistance of the recovery of different biomolecules from H. pluvialis.

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“…The demand for natural AX is strengthening but is challenged by current high production costs compared to the synthetic product. AX can be naturally synthesized at industrial scales by the microalgae Haematococcus pluvialis , the yeast Phaffia rhodozyma , or the gram‐negative bacteria Paraccoccus carotinifaciens (Johnson & An, 1991; X. Li et al, 2020; Luna‐Flores et al, 2010; Miyakawa, 2021; Mussagy et al, 2021). However, low AX yields and productivities of the naturally produced AX have limited its commercial potential to compete against the synthetic AX.…”

Section: Introductionmentioning

confidence: 99%

An enhanced electron transport chain improved astaxanthin production in Phaffia rhodozyma

Luna‐Flores

Wang²,

Cui

et al. 2023

Biotech & Bioengineering

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Astaxanthin (AX) is a carotenoid pigment with antioxidant properties widely used as a feed supplement. Wild‐type strains of Phaffia rhodozyma naturally produce low AX yields, but we increased AX yields 50‐fold in previous research using random mutagenesis of P. rhodozyma CBS6938 and fermentation optimization. On that study, genome changes were linked with phenotype, but relevant metabolic changes were not resolved. In this study, the wild‐type and the superior P. rhodozyma mutant strains were grown in chemically defined media and instrumented fermenters. Differential kinetic, metabolomics, and transcriptomics data were collected. Our results suggest that carotenoid production was mainly associated with cell growth and had a positive regulation of central carbon metabolism metabolites, amino acids, and fatty acids. In the stationary phase, amino acids associated with the TCA cycle increased, but most of the fatty acids and central carbon metabolism metabolites decreased. TCA cycle metabolites were in abundance and media supplementation of citrate, malate, α‐ketoglutarate, succinate, or fumarate increased AX production in the mutant strain. Transcriptomic data correlated with the metabolic and genomic data and found a positive regulation of genes associated with the electron transport chain suggesting this to be the main driver for improved AX production in the mutant strain.

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Commercial Production of Astaxanthin from the Green Alga Haematococcus pluvialis

Cited by 7 publications

References 20 publications

Carotenoides

Carotenoides

Extraction of Valuable Biomolecules from the Microalga Haematococcus pluvialis Assisted by Electrotechnologies

An enhanced electron transport chain improved astaxanthin production in Phaffia rhodozyma

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