Commercial<i>Carlinae radix</i>herbal drug: Botanical identity, chemical composition and antimicrobial properties

Stojanović-Radić, Zorica; Čomić, Ljiljana R.; Radulović, Niko S.; Blagojević, Polina D.; Mihajilov‐Krstev, Tatjana; Rajković, Jovana

doi:10.3109/13880209.2011.649214

Cited by 36 publications

(26 citation statements)

References 14 publications

(18 reference statements)

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“…Thus, several studies have confirmed the potential of carlina root EO and carlina oxide to inhibit and kill bacteria and fungi as compared with standard microbial drugs [97]. These findings strengthen the ethno-pharmaceutical use of carlina in the treatment of several human infections [88].…”

Section: Carlina Acaulis (And Related Species)mentioning

confidence: 57%

“…B. 6 (Appendix to German Pharmacopeia Sixth from 1941) [ 87 , 88 , 89 ]. Carlina acanthifolia is another widely distributed and less rare carlina species, considered as an adulterant or substitute for the root of C. acaulis [ 13 , 87 , 89 ].…”

Section: Essential Oils From Selected Rootsmentioning

confidence: 99%

“…Literature data indicate that the roots of carlina spp. mainly comprise inulin (18–20%), flavonoids, and 1–2% of an EO [ 89 , 91 , 92 ], with a quite simple profile [ 88 ]. However, its biological activity is mostly associated with the EOs.…”

Section: Essential Oils From Selected Rootsmentioning

confidence: 99%

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Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Lunz

Stappen

2021

Molecules

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Since ancient times, plant roots have been widely used in traditional medicine for treating various ailments and diseases due to their beneficial effects. A large number of studies have demonstrated that—besides their aromatic properties—their biological activity can often be attributed to volatile constituents. This review provides a comprehensive overview of investigations into the chemical composition of essential oils and volatile components obtained from selected aromatic roots, including Angelica archangelica, Armoracia rusticana, Carlina sp., Chrysopogon zizanioides, Coleus forskohlii, Inula helenium, Sassafras albidum, Saussurea costus, and Valeriana officinalis. Additionally, their most important associated biological impacts are reported, such as anticarcinogenic, antimicrobial, antioxidant, pesticidal, and other miscellaneous properties. Various literature and electronic databases—including PubMed, ScienceDirect, Springer, Scopus, Google Scholar, and Wiley—were screened and data was obtained accordingly. The results indicate the promising properties of root-essential oils and their potential as a source for natural biologically active products for flavor, pharmaceutical, agricultural, and fragrance industries. However, more research is required to further establish the mechanism of action mediating these bioactivities as well as essential oil standardization because the chemical composition often strongly varies depending on external factors.

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Section: Carlina Acaulis (And Related Species)mentioning

confidence: 57%

Section: Essential Oils From Selected Rootsmentioning

confidence: 99%

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Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Lunz

Stappen

2021

Molecules

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“…The number of data on the chemical composition of Carlina plants is limited. It has been reported that the root of C. acaulis contains inulin ( Đorđević et al, 2005 , 2007 , 2012 ; Stojanović-Radić et al, 2012 ), essential oil ( Đorđević et al, 2012 ), and trace amount of lupeol ( Strzemski et al, 2016 ). In the herb, such flavonoids as orientin, homoorientin, isoschaftoside, vitexin, apigenin 7- O -glucoside, and apigenin ( Raynaud and Rasolojaona, 1979 ; Đorđević et al, 2012 ) as well as chlorogenic acids ( Jaiswal et al, 2011 ) and pentacyclic triterpenes: lupeol, lupeol acetate, α-amyrin, β-amyrin, β-amyrin acetate, betulinic acid, oleanolic acid, and ursolic acid ( Strzemski et al, 2016 ) have been identified.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antiproliferative Activity of Extracts of Carlina acaulis subsp. caulescens and Carlina acanthifolia subsp. utzka

et al. 2017

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Various species of the Carlina genus have been used in traditional medicine in many countries to treat numerous skin disorders, including cancer. The objective of this work was to assess the anticancer properties of root and leaf extracts from Carlina acaulis subsp. caulescens and C. acanthifolia subsp. utzka. Anti-tumor properties of the extracts were explored using a tetrazolium-based cell viability assay and flow cytometric apoptosis analysis, followed by immunodetection of phosphoactive ERK1/2 in UACC-903, C32, and UACC-647 human melanoma cell lines. Normal human fibroblasts were used as a control. Leaf extracts inhibited the viability of all tested melanoma cell lines in a dose-dependent fashion while the fibroblasts were less sensitive to such extract. The root extracts inhibited the proliferation of UACC-903 and UACC-647 cells only at the highest doses (300 μg/mL). However, the C32 and fibroblast cells exhibited an increase in the cellular proliferation rate and no caspase activity was observed in response to the root extracts (100 μg/mL). An increase in caspase activity was observed in melanoma cells treated with the leaf extracts of both Carlina species. Leaf extracts from C. acaulis subsp. caulescens (100 μg/mL) inhibited proliferatory ERK1/2 in UACC-903 and C32 cells, as demonstrated by the decrease in ERK1/2 phosphorylation. No reduction in phospho-ERK1/2 was observed in the tested cell lines treated with the root extracts, apart from UACC-647 after incubation with the C. acanthifolia subsp. utzka root extract (100 μg/mL). There was no change in ERK1/2 phosphorylation in the fibroblasts. The extracts from the leaves and roots were analyzed by HPLC and the analysis showed the presence of triterpenes and phenolic acids as the main extract components. The research demonstrated that the extracts from the leaves of the plants were cytotoxic against the human melanoma line and induced apoptosis of the cells. The triterpene fraction present in the tested extracts may be responsible for this activity.

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“…Essential oil and decoction of Carlinae Radix ( Carlina acanthifolia L.) showed significant antimicrobial effect against Staphylococcus aureus [35]. Compounds from Artemisia are antiplasmodial and antitrypanosomal drugs, and could be an alternative drug against trichinellosis [36–38].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c Mice

Skopiński

Bałan

Kocik

et al. 2013

Mediators of Inflammation

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Anticancer activity of many herbs was observed for hundreds of years. They act as modifiers of biologic response, and their effectiveness may be increased by combining multiple herbal extracts . PERVIVO, traditional digestive herbal remedy, contains some of them, and we previously described its antiangiogenic activity. Numerous studies documented anticancer effects of nonsteroidal anti-inflammatory drugs. We were the first to show that sulindac and its metabolites inhibit angiogenesis. In the present paper the combined in vivo effect of multicomponent herbal remedy PERVIVO and nonsteroidal anti-inflammatory drug sulindac on tumor growth, tumor angiogenesis, and tumor volume in Balb/c mice was studied. These effects were checked after grafting cells collected from syngeneic sarcoma L-1 tumors into mice skin. The strongest inhibitory effect was observed in experimental groups treated with PERVIVO and sulindac together. The results of our investigation showed that combined effect of examined drugs may be the best way to get the strongest antiangiogenic and antitumor effect.

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CommercialCarlinae radixherbal drug: Botanical identity, chemical composition and antimicrobial properties

Cited by 36 publications

References 14 publications

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

In Vitro Antiproliferative Activity of Extracts of Carlina acaulis subsp. caulescens and Carlina acanthifolia subsp. utzka

Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c Mice

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