The original publication [1] was a short communication paper where a series of experiments were performed using a range of headspace oven temperatures and vial pressures to measure the resulting accuracy and precision of ethanol concentrations using headspace gas chromatography coupled to flame ionization detection (HS-GC-FID) analysis. This instrument is consistent with many used in the forensic community, though the data are specific to the model used in the reported studies. The main premise of this work is that often laboratories merely adopt manufacturers' recommendations regarding the use of their instruments, and may not actually perform studies to determine the robustness of their instrumental parameters. This paper was evaluating two of the more impactful parameters: vial pressurization and vial incubation temperature. In reading the comments authored by Tiscione [2] regarding our publication we have the following additional comments.(1) This work was merely evaluating the performance of the instrumentation, and was by no means a method validation study intended for commercial laboratory adoption. The authors would hope that any laboratory considering adaptation of their instrumental parameters would perform the necessary validation work to demonstrate compliance to their intended quality assurance plan or other requirements. In no way do we propose that these parameters be blindly adopted. It is not clear how this impression might have been given to Tiscione. (2) Tiscione mentions that 85 • C may be "questionable", but our work is actually recommending a decrease in oven temperature relative to the manufacturers recommendation of 100 • C. Again, our hope was that researchers may find a benefit in the experimental procedure used and the data presented when they consider adapting their laboratory protocols relative to manufacturer recommendations. Even in aqueous standards, we observed a benefit in the lowering of the oven temperature away from the original equipment manufacturer (OEM) specifications. (3) Tiscione correctly points out that our reported method detection limits (MDL's) of less than 0.002 g/dL are not in compliance with the MDL procedure we referenced [3]. We could have (should?) reacquired the data with a less concentrated standard for those specific studies, but the main point was that the precision of the analysis was positively affected, resulting in a lower calculated MDL. It may have been better to report variance and not MDL, but given how this calculation is performed they are related and we left this in for consistency against our benchmark, OEM, conditions. (4) Tiscione points out that we used a 500-µL sample volume and states that "many published methods" require a lower sample volume (ca. 100-µL), and cites 2 references including one