Comments on “Human health risk assessment of pharmaceuticals and personal care products in plant tissue due to biosolids and manure amendments, and wastewater irrigation”

Malchi, Tomer; Maor, Yehoshua; Chefetz, Benny

doi:10.1016/j.envint.2015.03.014

Cited by 22 publications

(12 citation statements)

References 31 publications

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“…In addition, the variable impact of different treatment technologies and storage conditions on antibiotic degradation is also a potential concern, particularly since some antibiotics (ciprofloxacin and ofloxacin) have been shown to be genotoxic [35]. Our data show that antibiotics remain at low levels in reclaimed water (<LOD to 183 ng/mL), but the effect of chronic human exposures to complex mixtures of antibiotics and other pharmaceuticals in reclaimed water is unclear and deserves further study [36]. …”

Section: Resultsmentioning

confidence: 99%

Antibiotic Concentrations Decrease during Wastewater Treatment but Persist at Low Levels in Reclaimed Water

Kulkarni

Olson

Raspanti

et al. 2017

IJERPH

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Reclaimed water has emerged as a potential irrigation solution to freshwater shortages. However, limited data exist on the persistence of antibiotics in reclaimed water used for irrigation. Therefore, we examined the fate of nine commonly-used antibiotics (ampicillin, azithromycin, ciprofloxacin, linezolid, oxacillin, oxolinic acid, penicillin G, pipemidic acid, and tetracycline) in differentially treated wastewater and reclaimed water from two U.S. regions. We collected 72 samples from two Mid-Atlantic and two Midwest treatment plants, as well as one Mid-Atlantic spray irrigation site. Antibiotic concentrations were measured using liquid-chromatography- tandem mass spectrometry. Data were analyzed using Mann-Whitney-Wilcoxon tests and Kruskal Wallis tests. Overall, antibiotic concentrations in effluent samples were lower than that of influent samples. Mid-Atlantic plants had similar influent but lower effluent antibiotic concentrations compared to Midwest plants. Azithromycin was detected at the highest concentrations (of all antibiotics) in influent and effluent samples from both regions. For most antibiotics, transport from the treatment plant to the irrigation site resulted in no changes in antibiotic concentrations, and UV treatment at the irrigation site had no effect on antibiotic concentrations in reclaimed water. Our findings show that low-level antibiotic concentrations persist in reclaimed water used for irrigation; however, the public health implications are unclear at this time.

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Section: Resultsmentioning

confidence: 99%

Antibiotic Concentrations Decrease during Wastewater Treatment but Persist at Low Levels in Reclaimed Water

Kulkarni

Olson

Raspanti

et al. 2017

IJERPH

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“…However, it may be still premature to draw a concrete conclusion, as there lacks a comprehensive assessment of the human health risks associated with exposure to PPCPs through edible crops (Malchi et al, 2015).…”

Section: Potential Human Exposurementioning

confidence: 99%

Plant uptake of pharmaceutical and personal care products from recycled water and biosolids: a review

Dodgen

Conkle

et al. 2015

Science of The Total Environment

318

154

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“…Transformations occurring in mammals can provide clues about reactions PPCPs may undergo in planta, since many enzymes responsible for transforming xenobiotics, including cytochromes P450 (CYP450s) are conserved across phyla . Carbamazepine is likely transformed in planta to 10,11-epoxycarbamazepine, a potentially genotoxic metabolite considered more toxic than carbamazepine, , which is also formed by mammalian liver enzymes and in wastewater treatment sludge. , Analysis of soil-plant systems for carbamazepine and two transformation products (10,11-epoxycarbamazepine and 10,11-dihydro-10,11-dihydroxy-carbamazepine) demonstrated the presence of both metabolites in soils, leaves, and fruits, but only 10,11-epoxycarbamazepine in roots. , The 10,11-epoxycarbamazepine-to-carbamazepine ratio was much higher in leaves than in roots, leading to the hypothesis that carbamazepine is metabolized primarily in leaves. Metabolism and/or uptake of metabolites may also occur in the roots.…”

Section: Transformation and Sequestration In Plantamentioning

confidence: 99%

Root Uptake of Pharmaceuticals and Personal Care Product Ingredients

Miller

Nason

Karthikeyan

et al. 2016

Environ. Sci. Technol.

399

259

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Crops irrigated with reclaimed wastewater or grown in biosolids-amended soils may take up pharmaceuticals and personal care product ingredients (PPCPs) through their roots. The uptake pathways followed by PPCPs and the propensity for these compounds to bioaccumulate in food crops are still not well understood. In this critical review, we discuss processes expected to influence root uptake of PPCPs, evaluate current literature on uptake of PPCPs, assess models for predicting plant uptake of these compounds, and provide recommendations for future research, highlighting processes warranting study that hold promise for improving mechanistic understanding of plant uptake of PPCPs. We find that many processes that are expected to influence PPCP uptake and accumulation have received little study, particularly rhizosphere interactions, in planta transformations, and physicochemical properties beyond lipophilicity (as measured by Kow). Data gaps and discrepancies in methodology and reporting have so far hindered development of models that accurately predict plant uptake of PPCPs. Topics warranting investigation in future research include the influence of rhizosphere processes on uptake, determining mechanisms of uptake and accumulation, in planta transformations, the effects of PPCPs on plants, and the development of predictive models.

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Comments on “Human health risk assessment of pharmaceuticals and personal care products in plant tissue due to biosolids and manure amendments, and wastewater irrigation”

Cited by 22 publications

References 31 publications

Antibiotic Concentrations Decrease during Wastewater Treatment but Persist at Low Levels in Reclaimed Water

Antibiotic Concentrations Decrease during Wastewater Treatment but Persist at Low Levels in Reclaimed Water

Plant uptake of pharmaceutical and personal care products from recycled water and biosolids: a review

Root Uptake of Pharmaceuticals and Personal Care Product Ingredients

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