Comments on Hughes JR. A review of recent reports on autism: 1000 studies published in 2007. Epilepsy &amp; Behavior 2008;13:425–437 and Hughes JR. Update on autism: A review of 1300 reports published in 2008. Epilepsy &amp; Behavior 2009;16:569–589.

Besag, Frank; Blackmon, Karen

doi:10.1016/j.yebeh.2014.10.007

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…There is evidence that epilepsy is associated with regression in ASD, though effect sizes are small and inconsistent methodology and definitions, of both regression and epilepsy, limit interpretation [Barger, Campbell, & Simmons, ; Besag & Blackmon, ; Gadow, Perlman, & Weber, ; Hrdlicka et al, ; Jack & Pelphrey, ; Oslejskova et al, ]. However, specific seizure types may increase risk of regression and this may be more apparent using a prospective approach.…”

Section: Evidence For Regression and Prevalence Ratesmentioning

confidence: 99%

Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research

et al. 2018

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The way in which the behavioral manifestations of autism spectrum disorder (ASD) emerge in infancy is variable. Regression-loss of previously acquired skills-occurs in a subset of children. However, the etiology and significance of regression remains unclear. Until recently, investigation of regression relied on retrospective report by parents or examination of home videos from early in life. However, home videos and retrospective report of the nature and timing of regression, and association with factors such as illness or immunization, is potentially subject to bias. The advent of prospective studies of infant siblings at familial high-risk of ASD has the potential to document regression as it occurs. Recent research has suggested that subtle loss of skills occurs in a larger proportion of children with ASD than previously assumed; however, there are few reports of clear-cut regressions, such as that involving dramatic loss of language and other established skills, in the prospective literature. This could be because of the following: clear-cut regression occurs less commonly than parent report suggests, study design limits the potential to detect regression, or there are differences between multiplex and simplex families in the rate of de novo genetic mutations and therefore regression risk. This review will bring together literature from retrospective and prospective research and attempt to reconcile diverging findings, with a specific focus on methodological issues. Changing conceptualizations of regression will be discussed, as well as etiological factors that may be associated with regression. The main challenges that need to be addressed to measure regression in prospective studies will be set out.Lay Summary: Regression-a loss of previously established skills-occurs in a subset of children with ASD. Parental recall is not always accurate but studying younger siblings of children with ASD, 10-20% of whom will develop ASD, should make it possible to measure regression as it occurs. Clear-cut regression, like loss of language, has not often been reported in infant sibling studies, but recent research suggests that gradual loss of social engagement might be more common. This review looks at the evidence for regression from infant sibling studies and asks how study design affects the likelihood of capturing regression.

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Section: Evidence For Regression and Prevalence Ratesmentioning

confidence: 99%

Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research

et al. 2018

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Parent-Reported Developmental Regression in Autism: Epilepsy, IQ, Schizophrenia Spectrum Symptoms, and Special Education

Gadow

Weber

2017

J Autism Dev Disord

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Examined the psychiatric and clinical correlates of loss of previously acquired skills (regression) as reported by parents of youth with autism spectrum disorder (ASD). Study sample comprised 6- to 18-year old (N = 213) children and adolescents with ASD. Parents reported regression in 77 (36%) youth. A more homogeneous subgroup with regression between 18 and 36 months (n = 48) had higher rates of intellectual disability, epilepsy, and special education, more socially restrictive educational settings, and more severe ASD communication deficits and schizophrenia spectrum symptoms than non-regressed youth (n = 136). Similar results were obtained for a more inclusive definition of regression (n = 77). A brief parent report of developmental regression may be a useful clinical indicator of later general functioning.

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Comments on Hughes JR. A review of recent reports on autism: 1000 studies published in 2007. Epilepsy & Behavior 2008;13:425–437 and Hughes JR. Update on autism: A review of 1300 reports published in 2008. Epilepsy & Behavior 2009;16:569–589.

Cited by 2 publications

References 32 publications

Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research

Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research

Parent-Reported Developmental Regression in Autism: Epilepsy, IQ, Schizophrenia Spectrum Symptoms, and Special Education

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