We consider D7-branes in the gauge theory/string theory correspondence, using a probe approximation. The D7-branes have four directions embedded holomorphically in a non-compact Calabi-Yau 3-fold (which for specificity we take to be the conifold) and their remaining four directions are parallel to a stack of D3-branes transverse to the Calabi-Yau space. The dual gauge theory, which has N = 1 supersymmetry, contains quarks which transform in the fundamental representation of the gauge group, and we identify the interactions of these quarks in terms of a superpotential. By activating three-form fluxes in the gravity background, we obtain a dual gauge theory with a cascade of Seiberg dualities. We find a supersymmetric supergravity solution for the leading backreaction effects of the D7-branes, valid for large radius. The cascading theory with flavors exhibits the interesting phenomenon that the rate of the cascade slows and can stop as the theory flows to the infrared.