Comments on "arterial CO2 myocardial O2 consumption and coronary blood flow in the dog.

Drake, Angela J.; Noble, Miriam

doi:10.1161/01.res.48.3.447

Cited by 1 publication

(2 citation statements)

References 6 publications

(10 reference statements)

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“…These data are in direct conflict with previous studies in that they can only attribute a small vasodilator capability to CO2, and do not support a role for CO2 in the metabolic regulation of coronary blood flow (Drake, Noble & Sparks, 1981).…”

Section: S W Ely D C Sawyer and J B Scottcontrasting

confidence: 99%

“…Recent studies have examined the effects of systemic alterations in arterial PCO2 on left coronary blood flow under natural flow (constant pressure) conditions, both with and without adrenergic blockade (van den Bos et al 1979;Rooke & Sparks, 1980;Ehrhart & Smith, 1980). These data are in direct conflict with previous studies in that they can only attribute a small vasodilator capability to CO2, and do not support a role for CO2 in the metabolic regulation of coronary blood flow (Drake, Noble & Sparks, 1981).…”

Section: Introductionmentioning

confidence: 96%

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Local vasoactivity of oxygen and carbon dioxide in the right coronary circulation of the dog and pig.

Ely¹,

Sawyer²,

Scott³

1982

The Journal of Physiology

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SUMMARY1. Eight mongrel dogs were anaesthetized with sodium thiamylal and chloraloseurethane, ventilated, vagotomized and heparinized. Five Poland-China pigs were anaesthetized with sodium thiamylal and nitrous oxide, ventilated, vagotomized and heparinized.2. Extracorporeal perfusion of the right coronary artery at constant pressure (100 mmHg) was instituted. A lung from a donor animal was interposed in the coronary perfusion circuit to effect changes in CO2 and 02 tensions in the coronary arterial blood while systemic blood gases were maintained at normal levels.3. Local hypoxia (PO2 range 17-22 mmHg) produced a 25-75% decrease in coronary vascular resistance (P < 0 05) and a 0-24 % (not significant) decrease in right ventricular dP/dt. 4. Local changes in Pco, over the range 8-105 mmHg were associated with a 17-58 % decrease in coronary vascular resistance (P < 0-05), a 19-24 % decrease in right ventricular dP/dt (P < 0-05) with no change in right ventricular end-diastolic pressure, and a 1-18 % (not significant) decrease in heart rate.5. These studies suggest that local decreases in 02 or increases in CO2 tensions produce decreases in right coronary vascular resistance that are in the opposite direction to those that would be expected from the observed changes in heart rate and contractility (two primary determinants of myocardial oxygen consumption).6. These data support the hypothesis that CO2 and 02 are locally vasoactive in the coronary circulation.

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Section: S W Ely D C Sawyer and J B Scottcontrasting

confidence: 99%