Comments on ‘An overview of space medicine’

Bevelacqua, Joseph John; Welsh, James S.; Mortazavi, S.M.J.

doi:10.1016/j.bja.2017.12.015

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…[17][18][19]. A recent publication confirms the key role of biological protection of astronauts [20], an issue discussed in detail in some new publications [21][22][23]. The consistency of our previous work [24,25] and others [26,27] was noted by Cortese et al who published this report.…”

Section: Discussionsupporting

confidence: 85%

Biological Protection in Deep Space Missions

Sihver

Mortazavi

2021

J Biomed Phys Eng

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Section: Discussionsupporting

confidence: 85%

Biological Protection in Deep Space Missions

Sihver

Mortazavi

2021

J Biomed Phys Eng

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“…The issue of adaptive response in space mission and its importance as an efficient method of biological protection dates back to 2003 [12]. Different aspects of this issue are well-discussed in our recent publications [13,14]. At first glance, it can be hypothesized that this response is entirely a protective adaptive response (e.g.…”

Section: A Telomere Length and Space Environmental Stressorsmentioning

confidence: 99%

Space Medicine: Why Do Recently Published Papers about Telomere Length Alterations Increase our Uncertainty Rather than Reduce it?

Bevelacqua¹,

Welsh

Mortazavi

et al. 2021

J Biomed Phys Eng

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There is a growing interest in examining alterations in telomere length as a reliable biomarker of general health, as well as a marker for predicting later morbidity and mortality. Substantial evidence shows that telomere length is associated with aging; telomere shortening acts as a “counting mechanism” that drives replicative senescence by limiting the mitotic potential of normal (but not malignant) cells. In this Correspondence, we attempt to answer the question of why recently published papers about telomere length alterations increase our uncertainty rather than reduce it. This discussion includes three major research areas regarding telomere length: environmental stressors, aging, and life span. Our review suggests that activation of telomerase activity due to stressors in space might be a double-edged sword with both favorable and unfavorable consequences. The selection of an effect’s consequence must clearly elucidate the experimental conditions as well as associated stressors. In this Correspondence, we attempt to answer the question of why recently published papers about telomere length alterations increase our uncertainty rather than reduce it. The selection of an effect’s consequence must clearly elucidate the experimental conditions as well as associated stressors. Both positive and negative consequences must be clearly addressed in order to bolster the conclusions, as well as identify future research directions.

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“…Evaluating a limited set of organic materials is not representative of the response of the human body to radiation. In particular, the effects of radioadaptation, the human immune system, and biological repair mechanisms should be evaluated in order to obtain a complete assessment of the potential health effects of radiation . Radioadaptation increases the body's resistance to higher doses of radiation after a pre‐exposure to a lower dose.…”

Section: Characterization Of the Leo Radiation Environmentmentioning

confidence: 99%

Commentary regarding: “The effect of simulated space radiation on the N‐glycosylation of human immunoglobulin G1”

Bevelacqua¹,

Mortazavi

2018

Electrophoresis

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Deep space missions, including Mars voyages, are an important area of research. Protection of astronauts' health during these long-term missions is of paramount importance. The paper authored by Szarka et al. entitled "The effect of simulated space radiation on the N-glycosylation of human immunoglobulin G1" is indeed a step forward in this effort. Despite numerous strengths, there are some shortcomings in this paper including an incomplete description of the space radiation environment as well as discussion of the resulting biological effects. Due to complexity of the space radiation environment, a careful analysis is needed to fully evaluate the spectrum of particles associated with solar particle events and galactic cosmic radiation. The radiation source used in this experiment does not reproduce the range of primary galactic cosmic radiation and solar particle events particles and their associated energies. Furthermore, the effect of radiation interactions within the spacecraft shell and the potential effects of microgravity are not considered. Moreover, the importance of radioadaptation in deep space missions that is confirmed in a NASA report is neither considered. Other shortcomings are also discussed in this commentary. Considering these shortcomings, it can be argued that Szarka et al. draw conclusions based on an incomplete description of the space radiation environment that could affect the applicability of this study.

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Comments on ‘An overview of space medicine’

Cited by 11 publications

References 9 publications

Biological Protection in Deep Space Missions

Biological Protection in Deep Space Missions

Space Medicine: Why Do Recently Published Papers about Telomere Length Alterations Increase our Uncertainty Rather than Reduce it?

Commentary regarding: “The effect of simulated space radiation on the N‐glycosylation of human immunoglobulin G1”

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