We consider input-output systems in descriptor form and ask when such systems can be rendered SPR (strictly positive real) via output feedback. Time and frequency domain conditions are given to determine when and how this is possible. In addition, a synthesis procedure for controller design is also derived. Together, the results provide a complete answer to when a linear descriptor system can be made SPR via output feedback, and give a recipe for design of the feedback controller when it exists. Simple examples are given to illustrate our results and to demonstrate their efficacy.