Persistence in a research career can be readily understood within the trainee models that have emerged from undergraduate and graduate instruction. These models offer a common language for discussing training processes, serve as guides for assessing trainee needs, promise to render training programs that are more comprehensive and attentive than are current programs to the factors that contribute to academic and scientific persistence, and enable us to measure with greater precision, internal consistency, and generalizability the elements that logically belong in research career developmentprograms. ( NUMEROUS PROGRAMS HAVE emerged in recent years to recruit junior investigators to the social, behavioral, and health sciences; to enhance their scholarly productivity; to increase their ability to secure externally sponsored research; and to improve the likelihood of their promotion within academia, thereby retaining them in their respective fields of inquiry. 1 the Native Investigator Development Program at the University of Colorado,8,9 and others. However, such programs typically have not been erected on a firm conceptual foundation; rather, they draw upon longstanding formulas, usually dictated by funding agencies, that cry out for theoretical reexamination.10 Surprisingly, despite decades of conceptually driven instruction at earlier levels of education, which has analogous goals, albeit tailored to undergraduate and graduate preparation, little of this thoughtfulness has found its way into postdoctoral or postresidency research training.A rich intellectual tradition is evident in the literature regarding the recruitment and retention of minority students in higher education.11-14 Much of it is rooted in Tinto's 15-17 general theory of academic persistence. His model asserts that students enter higher education with a variety of personal attributes (e.g., gender, culture), precollege experiences (grade-point averages, academic and social attainments), and family backgrounds (socioeconomic status, parental educational level), each of which has direct and indirect impacts upon performance in college. Furthermore, once these students are in college, Tinto argues that the degree to which they become integrated into the academic and social systems of their respective institutions is directly related to their commitment to that institution and, in turn, the greater likelihood they will complete college. This line of thought holds considerable merit for informing later points in the developmental trajectory of scientists-to-be. I have extended Tinto's model of student persistence to postdoctoral and postresidency training, with special emphasis on the individual, structural, and organizational elements particular to preparing for a successful career in social, behavioral, and health sciences research. This conceptual framework takes into account the broader, more fluid context of developing such a career. This framework includes the tasks and competencies-communicating across disciplines; formulating specific, funda...