Commentary: Our understanding of central serous chorioretinopathy—coming a full circle?

Mohan, Ashwin; Soman, Manoj; Nair, R Unnikrishnan

doi:10.4103/ijo.ijo_2152_19

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Furthermore, a study showed that SPX treatment could improve insulin resistance, dyslipidemia, oxidative stress, inflammation, apoptosis, and fibrosis [46]. Given that ACSCR is associated with oxidative stress and inflammation, the reduced levels of circulating SPX in this study may be due to the endogenous production of SPX to counteract these harmful effects [47]. However, as there are no other studies investigating this phenomenon, we cannot make any comparisons with other data.…”

Section: Discussionmentioning

confidence: 81%

Exploring the Potential Link between Acute Central Serous Chorioretinopathy and Trimethylamine N-Oxide, Phoenixin, Spexin, and Alarin Molecules

Kaya,

Arslan

2023

Biomolecules

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Purpose: Acute central serous chorioretinopathy (ACSCR) is a condition characterized by decreased visual acuity, macular thickening, and edema under the retinal layer. Although the underlying mechanisms of the disease are not fully understood, oxidative stress is considered to be a critical risk factor. The aim of this study was to shed light on the pathophysiology of ACSCR by investigating the levels of circulating trimethylamine N-oxide (TMAO), phoenixin (PNX), alarin (ALA), and spexin (SPX) molecules in ACSCR patients. Methods: The study included 30 ACSCR patients and 30 healthy individuals as controls. ACSCR was diagnosed using optical coherence tomography (OCT) imaging. Five mL blood samples were collected from all participants following overnight fasting. The levels of TMAO, PNX, ALA, and SPX in the blood samples were measured using the ELISA method. Results: Visual acuity was found to be significantly reduced in ACSCR patients compared to the control group (<0.05), while macular thickness was increased (<0.05). Furthermore, TMAO, PNX, and ALA levels were significantly higher in ACSCR patients (<0.05), while SPX levels were significantly lower compared to the control group (<0.05). In ACSCR patients, there was a positive correlation between macular thickness and TMAO, PNX, and ALA; there was, however, a negative correlation with SPX. Additionally, visual acuity was negatively correlated with TMAO, PNX, and ALA, while SPX levels decreased as visual acuity decreased. Conclusions: These results demonstrate a correlation between the TMAO, PNX, ALA, and SPX levels of ACSCR patients and their visual acuity and macular thickness. Given the role of these molecules in ACSCR’s pathophysiology, they hold promise as potential diagnostic, therapeutic, and follow-up markers in the future.

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