characteristics of the aorta in LDS versus MFS patients. In the setting of AAD, it is the practice at Johns Hopkins to perform the distal anastomosis open, presumably regardless of the patient's genotype. Likewise, unless the arch is enlarged, it is their practice to clamp the aorta just proximal to the innominate artery. Atraumatic clamps are not atraumatic, and injury to the media and/or intima with clamping may lead to downstream effects. If the tissue of Loey-Dietz is more vulnerable to crush injury it would stand to reason that subsequent pathology could follow.The tear-directed and pathology-oriented approach by the team at Johns Hopkins continues to lead the way in the diagnosis and management of connective tissue disorders. This latest study adds to our understanding of the subtle differences in these potentially deadly diseases.