Commentary on Singh et al. (2016): Still searching for the answer

Abstract

Commentary on Singh et al. (2016): Still searching for the answer Pharmacotherapy trials for psychostimulant dependence have a long history, and no proven, effective drug has emerged. With attention turning to anticonvulsants, the work by Singh et al. is cautionary in that, again, the drug in question did not emerge as clearly effective.

Kichik Biznes Subyektlarining Ishlab Chiqarishini Samarali Amalga Oshirish Ko'rsatkichlari

“…Muvaffaqiyatli boʻlish uchun har bir kichik biznes subyekt vaziyatga strategik ahamiyatga ega boʻlgan samaradorlik koʻrsatkichlarini belgilashi kerak [21]. Subyektiv samaradorlik koʻrsatkichlari (masalan, mijozlar ehtiyojini qondirish) mustaqil tomon tomonidan baholanmaydigan yoki tekshirilmaydigan, ammo soʻrovlar va intervyular orqali toʻplangan fikrlar yoki tasavvurlarga asoslanadi [22]. Subyektiv choralar tarafkashlikni kamaytirish va xavfni kamaytirish uchun ishlatilishi mumkin.…”

How can we investigate the role of topiramate in the treatment of cocaine use disorder more thoroughly?

“…We read with interest Darke & Farrell’s [1] commentary on our meta-analysis of topiramate published in the eighth issue of 2016 [2]. To elaborate on some of the ideas raised by the commentary, we focus our response on the question of why some studies implied a benefit and others did not.…”

“…Robust evaluations of this kind require uniform outcome measures and comparable populations that are amenable to pooling in meta-analyses and that may come later, as the literature on this molecule matures. Until such designs arrive, we will still keep ‘searching for the answer’ to the open question about the role of topiramate in the cocaine use disorder treatment, as posed in Darke & Farrell’s commentary [1]. …”