Commentary on “Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV‐2 neuroinvasion”

Chang, Sulie L.; Zhang, Jonathan

doi:10.1111/acer.15122

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…To determine the quantitative impact of these qualitative relationships found using the MAP tool, downstream effect analysis was performed as described previously [20,[33][34][35][36]. The analysis determines the significance of a molecule's effect on either another molecule or a signaling pathway by quantifying the relationship between the nodes on IPA.…”

Section: Quantitative Analysis Of Covid-19 On Snca Expression and The...mentioning

confidence: 99%

“…There have been 20 case studies as of 2022 that have shown new onset of parkinsonism symptoms such as bradykinesia and/or rigidity during or shortly after the diagnosis of COVID-19 [17]. Furthermore, studies have shown that the suggested worsening of the pathology of PD patients may be due to viral postencephalitic parkinsonism, while others suggest that SARS-CoV-2 neuroinvasion may be responsible [17,19,20].…”

Section: Introductionmentioning

confidence: 99%

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Meta-Analysis of the Mechanisms Underlying COVID-19 Modulation of Parkinson’s Disease

Zhang,

Bishir,

Barbhuiya

et al. 2023

IJMS

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Coronavirus disease-19 (COVID-19) is caused by the infection of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The virus enters host cells through receptor-mediated endocytosis of angiotensin-converting enzyme-2 (ACE2), leading to systemic inflammation, also known as a “cytokine storm”, and neuroinflammation. COVID-19’s upstream regulator, interferon-gamma (IFNG), is downregulated upon the infection of SARS-CoV-2, which leads to the downregulation of ACE2. The neuroinflammation signaling pathway (NISP) can lead to neurodegenerative diseases, such as Parkinson’s disease (PD), which is characterized by the formation of Lewy bodies made primarily of the α-synuclein protein encoded by the synuclein alpha (SNCA) gene. We hypothesize that COVID-19 may modulate PD progression through neuroinflammation induced by cytokine storms. This study aimed to elucidate the possible mechanisms and signaling pathways involved in COVID-19-triggered pathology associated with neurodegenerative diseases like PD. This study presents the analysis of the pathways involved in the downregulation of ACE2 following SARS-CoV-2 infection and its effect on PD progression. Through QIAGEN’s Ingenuity Pathway Analysis (IPA), the study identified the NISP as a top-five canonical pathway/signaling pathway and SNCA as a top-five upstream regulator. Core Analysis was also conducted on the associated molecules between COVID-19 and SNCA to construct a network connectivity map. The Molecule Activity Predictor tool was used to simulate the infection of SARS-CoV-2 by downregulating IFNG, which leads to the predicted activation of SNCA, and subsequently PD, through a dataset of intermediary molecules. Downstream effect analysis was further used to quantify the downregulation of ACE2 on SNCA activation.

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Section: Quantitative Analysis Of Covid-19 On Snca Expression and The...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of the Mechanisms Underlying COVID-19 Modulation of Parkinson’s Disease

Zhang,

Bishir,

Barbhuiya

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Meta-Analysis of the Mechanisms Underlying COVID-19 Modulation of Parkinson’s Disease

Zhang¹,

Bishir²,

Barbhuiya³

et al. 2023

Preprint

View full text Add to dashboard Cite

Coronavirus Disease-19 (COVID-19) is caused by the infection of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The virus enters host cells through receptor-mediated endocytosis of angiotensin-converting enzyme-2 (ACE2), leading to systemic inflammation, also known as a “cytokine storm,” and neuroinflammation. COVID-19’s upstream regulator, interferon-gamma (IFNG), is downregulated upon the infection of SARS-CoV-2, which leads to the downregulation of ACE2. The neuroinflammation signaling pathway (NISP) can lead to neurodegenerative diseases, such as Parkinson's disease (PD), which is characterized by the formation of Lewy Bodies made of α-Synuclein protein encoded by synuclein alpha (SNCA). This study presents the pathways involved in the downregulation of ACE2 following SARS-CoV-2 infection and its effect on PD progression. Through QIAGEN’s Ingenuity Pathway Analysis, the study identifies the NISP as a top-five canonical pathway/signaling pathway and SNCA as a top-five upstream regulator. Core Analysis was also conducted on the associated molecules between COVID-19 and SNCA to construct a network connectivity map. The Molecule Activity Predictor tool was used to simulate the infection of SARS-CoV-2 by downregulating IFNG, which leads to the predicted activation of SNCA, and subsequently PD, through a dataset of intermediary molecules. Downstream Effect analysis was further used to quantify the downregulation of ACE2 on SNCA activation.

show abstract

Commentary on “Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV‐2 neuroinvasion”

Cited by 2 publications

References 19 publications

Meta-Analysis of the Mechanisms Underlying COVID-19 Modulation of Parkinson’s Disease

Meta-Analysis of the Mechanisms Underlying COVID-19 Modulation of Parkinson’s Disease

Meta-Analysis of the Mechanisms Underlying COVID-19 Modulation of Parkinson’s Disease

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