“…In the HMA maintenance group, the overall survival and the relapse-free survival were superior; the cumulative incidence of relapse and non-relapse mortality were lower than in the observation group. However, some limitations of this study were reported in a commentary by Beauvais et al ( 9 ), who believed an inaccurate approach to data design and analyses led to an immortal time bias. These authors argued that only a randomized study can demonstrate a definitive conclusion.…”