Commentary

Soricelli, Rhonda L.

doi:10.1097/00001888-200611000-00014

Cited by 1 publication

(1 citation statement)

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“…However, it is plausible that there is also domain specificity to reserve and that this varies between people. For example, artistic and verbal abilities could be maintained to very different degrees in the face of dementia (Soricelli, 2006). Our results showed a modest positive effect of midlife cognitive activity on semantic memory reserve whereas its effects on episodic memory and fluency reserve were weakly negative.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Activities During Adulthood Are More Important than Education in Building Reserve

Reed

Dowling

Farias

et al. 2011

J Int Neuropsychol Soc

109

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Cognitive reserve is thought to reflect life experiences. Which experiences contribute to reserve and their relative importance is not understood. Subjects were 652 autopsied cases from the Rush Memory and Aging Project and the Religious Orders Study. Reserve was defined as the residual variance of the regressions of cognitive factors on brain pathology and was captured in a latent variable that was regressed on potential determinants of reserve. Neuropathology variables included Alzheimer’s disease markers, Lewy bodies, infarcts, microinfarcts, and brain weight. Cognition was measured with six cognitive domain scores. Determinants of reserve were socioeconomic status (SES), education, leisure cognitive activities at age 40 (CA40) and at study enrollment (CAbaseline) in late life. The four exogenous predictors of reserve were weakly to moderately inter-correlated. In a multivariate model, all except SES had statistically significant effects on Reserve, the strongest of which were CA40 (β= .31) and CAbaseline (β= .28). The Education effect was negative in the full model (β= −.25). Results suggest that leisure cognitive activities throughout adulthood are more important than education in determining reserve. Discrepancies between cognitive activity and education may be informative in estimating late life reserve.

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Section: Discussionmentioning

confidence: 99%