“…While comorbidity is often dismissed as an artifact of our diagnostic systems, some comorbidity may be attributable to different stages of illness (e.g., much psychopathology may begin as non-specific distress, Zachar, 2023). Although this research should also be evaluated critically (Lorenzo-Luaces et al, 2021;Lorenzo-Luaces, 2023), mechanistically-informed personalized approaches that are tailored to different stages and targets of psychopathology may be one path towards improved outcomes.…”