Commentary: cumulative risk assessment of perfluoroalkyl carboxylic acids and perfluoralkyl sulfonic acids: what is the scientific support for deriving tolerable exposures by assembling 27 PFAS into 1 common assessment group?

Colnot, Thomas; Dekant, W.

doi:10.1007/s00204-022-03336-9

Cited by 7 publications

(2 citation statements)

References 40 publications

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“…For rodents and other non-avian vertebrates, there is also a shortage of PFAS toxicity studies for wild populations. A 'no-observed-adverse-effect-concentration' (NOAEC) of 50,000 ng/mL has been estimated as repeated dose toxicity in rodent serum (Colnot and Dekant, 2022); but just as is the case in birds, adverse effects have been reported at far lower concentrations.…”

Section: Effects On Animal Healthmentioning

confidence: 99%

Extraordinary levels of per- and polyfluoroalkyl substances (PFAS) in vertebrate animals at a New Mexico desert oasis: Multiple pathways for wildlife and human exposure

Witt,

Gadek,

Cartron

et al. 2024

Environmental Research

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Section: Effects On Animal Healthmentioning

confidence: 99%

Extraordinary levels of per- and polyfluoroalkyl substances (PFAS) in vertebrate animals at a New Mexico desert oasis: Multiple pathways for wildlife and human exposure

Witt,

Gadek,

Cartron

et al. 2024

Environmental Research

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“…To overcome the problems associated with estimating TEFs, Colnot and Dekant (2022) proposed a classification strategy for PFAS that divides them into two distinct groups: PFCA and PFSA. The authors concluded that PFAS with short chains or non-linear structures should not be included in either group because of their low toxicological potency and rapid elimination [51]. Evans et al (2022) conducted an analysis to assess the ability of 16 PFAS compounds to activate PPARα, human and rat PPARγ, and other receptors.…”

Section: The Lack Of Scientific Basis For the Application Of The Toxi...mentioning

confidence: 99%

The EU’s Per- and Polyfluoroalkyl Substances (PFAS) Ban: A Case of Policy over Science

Spyrakis,

Dragani

2023

Toxics

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The proposal by the European Chemicals Agency (ECHA) to ban over 12,000 per- and polyfluoroalkyl substances (PFAS) has sparked a debate about potential consequences for the economy, industry, and the environment. Although some PFAS are known to be harmful, a blanket ban may lead to significant problems in attempting to replace PFAS-based materials for environmental transition, as well as in medical devices and everyday products. Alternative materials may potentially be less safe, as a rush to replace PFAS would reduce the time needed for toxicological analyses. Studies have shown that PFAS exhibit a diverse range of mechanisms of action, biopersistence, and bioaccumulation potential, and should thus not be treated as a single group. This is particularly true for the class of fluoropolymers. A targeted approach that considers the specific risks and benefits of each chemical may be more effective. Moreover, the proposed ban may also have unintended consequences for the environment as PFAS use is also associated with benefits such as reducing greenhouse-gas emissions and improving energy efficiency. Policymakers must carefully weigh up the potential consequences before making a final decision on the ban.

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Ubiquitous occurrence of organophosphate esters in plastic-made and paper-made food contact materials and their implication for human exposure

Wang,

Liu,

Jiang

et al. 2024

J Consum Prot Food Saf

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Commentary: cumulative risk assessment of perfluoroalkyl carboxylic acids and perfluoralkyl sulfonic acids: what is the scientific support for deriving tolerable exposures by assembling 27 PFAS into 1 common assessment group?

Cited by 7 publications

References 40 publications

Extraordinary levels of per- and polyfluoroalkyl substances (PFAS) in vertebrate animals at a New Mexico desert oasis: Multiple pathways for wildlife and human exposure

Extraordinary levels of per- and polyfluoroalkyl substances (PFAS) in vertebrate animals at a New Mexico desert oasis: Multiple pathways for wildlife and human exposure

The EU’s Per- and Polyfluoroalkyl Substances (PFAS) Ban: A Case of Policy over Science

Ubiquitous occurrence of organophosphate esters in plastic-made and paper-made food contact materials and their implication for human exposure

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