“…When assessing clinical interventions targeting complex conditions with low prevalence, such as children with autism spectrum disorder and comorbid depressive symptoms and suicidal ideation (Wijnhoven et al., ), target populations may be very small, which makes it difficult to conduct a meaningful RCT with sufficient statistical power. When assessing interventions in dynamic and challenging real‐world settings, such as in low‐ and middle‐income countries that are comprised of vulnerable population or affected by man‐made or natural disasters, it may be difficult to implement the intervention with good integrity, to standardize outcome assessment, or to map and properly control for other ongoing interventions targeting the same populations (Grolnick et al., ; Strouse & Moore, 2019, this issue).…”