Commentary: A classification system for antimicrobial activity based on MIC-values: Fake or reality?

Roersch, Carles

doi:10.1016/j.jep.2011.11.019

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Menurut kategori aktivitas antibakteri berdasarkan KHM yaitu kuat jika ≤0,5 mg/mL, sedang (0,6-1,5 mg/mL), lemah (≥ 1,6 mg/mL) maka ekstrak akar anting-anting yang diteliti pada penelitian ini memiliki aktivitas lemah terhadap MRSA dan S. aureus. 21 Metabolit sekunder yang berperan sebagai antibakteri pada ekstrak akar anting-aanting yaitu senyawa golongan fenol dan alkaloid.…”

Section: Hasil Penentuan Konsentrasi Hambatunclassified

Aktivitas Ekstrak Akar Anting-Anting (Acalypha indica) terhadap Pertumbuhan Staphylococcus aureus Sensitif dan Resisten

Rostinawati,

Chaniago,

Zuhrotun

2023

ijbp

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Staphylococcus aureus merupakan salah satu bakteri yang paling sering menginfeksi manusia. Bakteri tersebut dapat menjadi resisten dan membentuk biofilm sehingga menyulitkan pengobatan infeksi. Salah satu cara mengatasi infeksi selain obat yaitu dengan menggunakan bahan alam. Tanaman yang memiliki potensi sebagai antibakteri yaitu tanaman anting-anting. Penelitian ini dilakukan untuk menguji aktivitas tanaman tersebut terhadap pertumbuhan S. aureus dan Methicillin-Resistant Staphylococcus aureus. Metode yang digunakan meliputi ekstraksi, uji kandungan kimia dengan Gas Chromatography Mass Spectrometry, uji aktivitas antibakteri metode sumuran, penentuan konsentrasi hambat minimum, dan uji penghambatan pembentukan biofilm. Senyawa dengan aktivitas antibakteri yang ditemukan pada kedua ekstrak yaitu hexadecanoic acid methyl ester, metil ferulat dan actinidine. Hasil penelitian menunjukkan nilai KHM ekstrak akar anting-anting terhadap S. aureus dan MRSA yaitu 50 dan 100 mg/mL

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Section: Hasil Penentuan Konsentrasi Hambatunclassified

Aktivitas Ekstrak Akar Anting-Anting (Acalypha indica) terhadap Pertumbuhan Staphylococcus aureus Sensitif dan Resisten

Rostinawati,

Chaniago,

Zuhrotun

2023

ijbp

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“…In a paper entitled "A classification system for antimicrobial activity based on MIC values: Fake or reality? ", Roersch [22] questioned why there could be such an enormous variation in what authors considered good antimicrobial activity for plant extracts. In this paper, I will attempt to provide a rational basis for the classification of the activity of plant extracts after determining the antimicrobial activity of 714 acetone extracts of tree leaves from 537 tree species against 6 important bacterial and yeast pathogens.…”

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confidence: 99%

A Proposal Towards a Rational Classification of the Antimicrobial Activity of Acetone Tree Leaf Extracts in a Search for New Antimicrobials

Eloff

2021

Planta Med

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Many scientists investigate the potential of finding new antibiotics from plants, leading to more than a thousand publications per year. Many different minimum inhibitory concentrations of extracts have been proposed to decide if an extract has interesting activity that could lead to the discovery of a new antibiotic. To date, no rational explanation has been given for the selection criteria different authors have used. The cumulative percentage of plant extracts with different activities from a large experiment determining the activity of 714 acetone tree leaf extracts of 537 different South African tree species against 4 nosocomial pathogenic bacteria and 2 yeasts was calculated using a widely accepted serial dilution microplate method with p-iodonitrotetrazolium violet as indicator of growth. All the extracts were active at a concentration of 2.5 mg/mL. The formula, % of active extracts = 439 × minimum inhibitory concentration in mg/mL1.5385, describes the results for minimum inhibitory concentrations below 0.16 mg/mL, with a correlation coefficient of 0.9998. A rational approach could be to determine the minimum inhibitory concentrations of the most active 1, 3, 9, 25, 50, and > 50% of a large number of plant extracts investigated against these six important microbial pathogens. Starting with an extract concentration of 10 mg/mL, I propose the following classification based on minimum inhibitory concentrations: outstanding activity < 0.02 mg/mL, excellent activity 0.021 – 0.04 mg/mL, very good activity 041 – 0.08 mg/mL, good activity 0.081 – 0.16 mg/mL, average activity 0.161 – 0.32 mg/mL, and weak activity > 0.32 mg/mL. Higher minimum inhibitory concentrations may still be effective in ethnopharmacological studies.

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In Vitro Antimicrobial Activity of Natural Products Using Minimum Inhibitory Concentrations: Looking for New Chemical Entities or Predicting Clinical Response

Bueno¹

2012

Med Aromat Plants

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Commentary: A classification system for antimicrobial activity based on MIC-values: Fake or reality?

Cited by 3 publications

References 4 publications

Aktivitas Ekstrak Akar Anting-Anting (Acalypha indica) terhadap Pertumbuhan Staphylococcus aureus Sensitif dan Resisten

Aktivitas Ekstrak Akar Anting-Anting (Acalypha indica) terhadap Pertumbuhan Staphylococcus aureus Sensitif dan Resisten

A Proposal Towards a Rational Classification of the Antimicrobial Activity of Acetone Tree Leaf Extracts in a Search for New Antimicrobials

In Vitro Antimicrobial Activity of Natural Products Using Minimum Inhibitory Concentrations: Looking for New Chemical Entities or Predicting Clinical Response

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