Comment to the article by Arai Y, Jo T, Matsui H, Kondo T and Takaori-Kondo A: “Comparison of up-front treatments for newly diagnosed immune thrombocytopenia – a systematic review and network meta-analysis”. Haematologica 2018;103(1):163–171. Need to direct immune thrombocytopenia therapy towards shared goals

Abstract

On the basis of the results of their recent work titled "Comparison of up-front treatments for newly diagnosed immune thrombocytopenia -a systematic review and network meta-analysis", Arai and colleagues sustain that human thrombopoietin agonists may be beneficial up-front therapies in addition to conventional corticosteroid monotherapy in adults with primary immune thrombocytopenia, and that head-to-head trials including these regimens and rituximab-containing treatments are necessary to determine the most suitable therapies for these patients. Such head-to-head trials would, however, clash with the treatment currently foreseen for adults with newly diagnosed primary and severe immune thrombocytopenia which is not actually directed at modifying the natural history of the disease, but at 'achieving, rapidly, a safe platelet count to prevent or stop hemorrhages and to ensure an acceptable quality of life, avoiding, as much as possible, treatment-related adverse effects'. This fact and the lack of evidence that intensive medical therapy administered early in the disease course may improve or even cure immune thrombocytopenia mean that some treatments, including rituximab, are not, at present, acceptable as first-line therapy. In consideration of the potential usefulness of thrombopoietin agonists in up-front treatment for newly diagnosed immune thrombocytopenia, head-to-head trials similar to those proposed by Arai and colleagues would require a preliminary agreement on the goal of this line of therapy, just as we have sustained for other lines of immune thrombocytopenia therapy. This is to prevent exacerbating the disagreements already existing between different guidelines on the treatment of immune thrombocytopenia.In a recent article in Haematologica, Arai and colleagues reported the results of a systematic review and network meta-analysis comparing the efficacy and safety of different treatments utilized in adults for primary newly diagnosed immune thrombocytopenia (ITP). 1The study found that the main outcome, represented by a sustained response (platelet count >30x10 9 /L for 3-6 months after completion of treatments), was achieved by a significantly higher proportion of patients treated with recombinant human thrombopoietin agonists + dexamethasone or rituximab + dexamethasone than by those treated with conventional prednisolone or dexamethasone monotherapy. Moreover, with regards to the two secondary endpoints considered, overall response (defined as a platelet count >30x10 9 /L for 2-4 weeks after initiation of the upfront treatment) and therapy-related adverse events, thrombopoietin agonists + dexamethasone and thrombopoietin agonists + prednisolone improved early overall responses compared to prednisolone, dexamethasone, and rituximabcontaining regimens, while all treatments were tolerated and the therapy-related adverse event profiles were similar in all treatment arms. 1These results led the authors to claim that thrombopoietin agonists may be beneficial up-front therapies in addition to conventional ...