Comment on Yang et al. Association of Statin Use and Reduced Risk of Lower-Extremity Amputation Among Patients With Diabetes: A Nationwide Population-Based Cohort Observation. Diabetes Care 2016;39:e54–e55

Longitudinal trends and predictors of statin use among patients with diabetes

“…1–3 Statins may also reduce the risk of diabetic complications, such as foot ulcers and amputations. 4–6 Benefits of statins are not restricted to patients with marked hyperlipidemia or known cardiovascular disease. 7…”

Response to Comment on Yang et al. Association of Statin Use and Reduced Risk of Lower-Extremity Amputation Among Patients With Diabetes: A Nationwide Population-Based Cohort Observation. Diabetes Care 2016;39:e54–e55

“…We thank Fox et al (1) for their noteworthy comments concerning the need for clinical trials regarding the role of statins in preserving the lower extremities of patients with diabetes mellitus (DM). Complications of the extremities, comprising peripheral artery disease, peripheral neuropathy, foot ulcer, critical limb ischemia, and ultimately limb loss, constitute a huge health burden for patients with DM.…”