Comment on “Treatment of male pattern alopecia with platelet-rich plasma: A double-blind controlled study with analysis of platelet number and growth factor levels”

Altunel, Cemile Tuğba; Güleç, A. Tülin

doi:10.1016/j.jaad.2019.07.043

Cited by 2 publications

(1 citation statement)

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“…The best mode of PRP delivery is generally considered to be intradermal injection ( 56 ) as the proposed therapeutic mechanism of PRP is the activation of stem cells which, in turn, target the hair bulge and dermal papilla cells located in the dermis ( 39 , 40 ). Interestingly, Rodrigues et al ( 18 ) achieved hair growth by subcutaneous injections, suggesting that mechanical stimulation alone may also promote hair growth.…”

Section: Discussionmentioning

confidence: 99%

Platelet-rich Plasma for Androgenetic Alopecia Treatment: A Randomized Placebo-controlled Pilot Study

Gressenberger

Pregartner²,

Gary³

et al. 2020

Acta Derm Venereol

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Platelet-rich plasma injections have been presented as an effective treatment for androgenetic alopecia; however, reliable study data concerning this therapy are lacking. The current randomized, placebo-controlled pilot study explored this novel therapy in 30 healthy male subjects with androgenetic alopecia. Five platelet-rich plasma treatments, at intervals of 4–6 weeks, and 2 follow-up examinations were performed. Twenty subjects were injected intracutaneously with platelet-rich plasma and 10 with physiological saline. Treatment efficacy was assessed by changes in hair number and diameter, measured with the TrichoScan system. A secondary objective was to assess clinical improvement, which was evaluated by an independent reviewer using patient photographs and a 5-point Likert scale. In addition, subject satisfaction was assessed by survey. No improvements were seen over the course of the trial, using TrichoScan measurements or visual assessment. In conclusion, these results suggest that treatment with platelet-rich plasma as a monotherapy does not improve hair growth in men with androgenetic alopecia.

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Section: Discussionmentioning

confidence: 99%