Comment on “Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis”

Szaryńska, Magdalena; Olejniczak-Kęder, Agata

doi:10.1002/adma.201900747

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…[23][24][25][26] In present study, bioactive peptides neurotensin 1-10 and dynorphin A were found in kefir, which possess anti-hypertensive and antinociceptive properties, respectively. [27][28][29] In addition, functional organic substances, such as saponins, triterpenoids, flavonoids, alkaloids, and the like were identified in kefir (Table S5, Supporting Information), which are the bioactive compounds commonly implicated with the therapeutic potential of kefir. [30]…”

Section: Metabolite Composition Of Kefirmentioning

confidence: 99%

Kefir Ameliorates Alcohol‐Induced Liver Injury Through Modulating Gut Microbiota and Fecal Bile Acid Profile in Mice

Cui,

Jing,

Yue

et al. 2023

Molecular Nutrition Food Res

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ScopeAlcoholic liver disease (ALD) is the leading cause of liver‐related deaths worldwide. Kefir has been studied for its properties of anti‐obesity, rebuilding intestinal homeostasis, and alleviating non‐alcoholic fatty liver disease. However, the possible role of kefir in the prevention or treatment of ALD has not been carefully considered. Here, it evaluated the protective effects of kefir supplementation on alcohol‐induced liver injury.Methods and resultsC57BL/6J mice are fed to Lieber‐DeCarli liquid diet containing alcohol to build ALD mouse model, followed by oral administration with kefir. Results indicate that kefir treatment improves liver pathological changes, decreases the expression levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and inflammatory markers, and increases antioxidant levels. Kefir supplementation also restores the intestinal barrier and altered microbial composition, indicates as increases of Blautia, Bacteroides, and Parasutterella and decreases in the Firmicutes/Bacteroidetes (F/B) ratio and populations of Psychrobacter, Bacillus, and Monoglobus. Moreover, kefir supplementation decreases the levels of total bile acids (BAs) and primary BAs and increases the secondary/primary BA ratio. Gut microbes play a key role in the conversion of primary to secondary fecal BAs.ConclusionKefir can ameliorate ALD through regulating the composition of the gut microbiota.

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