“…A comprehensive review on the role of echocardiography in PAH that includes technical information on the new techniques in use, and emphasizes the need for testing, standardization and precise methodology offers useful detailed information on the technique [ 7 ]. The related comment by Manzi et al, that followed, emphasizes the need of including in the echocardiographic testing indices reflecting the pathophysiological changes that occur in the process of the disease and which, most importantly, would test the effect of specific PAH therapies [ 8 ].…”