Comment on: The role of posterior vitreous detachment on the efficacy of anti–vascular endothelial growth factor intravitreal injection for treatment of neovascular age-related macular degeneration

Awasthi, Upma; Grover, Rohini; Videkar, Chetan; Varshney, Abhishek

doi:10.4103/ijo.ijo_160_19

Cited by 1 publication

(1 citation statement)

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“…It could be supported that since VMA is indicated as a potential risk factor for the development of exudative active AMD, complete PVD could act as a protective factor reasonably raising the concept of protective pharmaceutic vitreolysis or even vitrectomy in high risk patients for exudative AMD. [27][28][29]…”

Section: Discussionmentioning

confidence: 99%

Posterior Vitreous Detachment and Its Role in the Evolution of Dry to Wet Age Related Macular Degeneration

Bakaliou¹,

Georgakopoulos²,

Farmakakis³

2023

OPTH

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Purpose To examine the state of the posterior vitreous in eyes with exudative age-related macular degeneration, AMD, non-exudative AMD and in normal eyes. Study This is a prospective, cross-sectional study. Methods B-scan ultrasonography and Optical Coherence Tomography, OCT were performed in 165 patients older than 65 years with any AMD and in 22 patients older than 65 years with normal eyes in order to diagnose the eyes with complete posterior vitreous detachment, PVD and the eyes with persistent central vitreomacular adhesion, VMA. All patients were selected from the outpatient clinic of the Ophthalmology Department in the University Hospital of Patras. Fundus Fluoroangiography, FFA was used in order to determine the development of exudative AMD from non-exudative AMD. Follow up time was 48 months. Results 16/171 eyes with exudative AMD (9.36%) had complete PVD, and the rest 155/171 (90.64%) had central VMA. Eleven of 138 eyes with non-exudative AMD (7.97%) had complete PVD and the remaining 127 eyes (92.03%) had central VMA. During the 48 months of the study, 28 eyes, all with central VMA progressed to exudative AMD. Conclusion Vitreomacular adhesion is associated with both exudative and non-exudative AMD. Progression of the non-exudative eyes to exudative AMD seems to be lower in eyes with complete PVD. On the other hand, the progression of normal eyes to exudative AMD appears to be independent of the posterior vitreous status. Larger and longer studies need to replicate these findings and support the potential of a protective role of complete posterior vitreous detachment in the evolution of the disease.

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Section: Discussionmentioning

confidence: 99%