Comment on: “The consequences of gynaecological cancer in patients and their partners from the sexual and psychological perspective”

Vitale, Salvatore Giovanni; Rosa, Valentina Lucia La; Rapisarda, Agnese Maria Chiara; Laganà, Antonio Simone

doi:10.5114/pm.2016.63501

Cited by 14 publications

(10 citation statements)

References 9 publications

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“…The lifespan of women suffering from cancer continues to increase thanks to the curative treatments currently available. However, it is also well-known that cancer treatments are often associated with decreased quality of life, for instance sexual dysfunction [ 56 , 57 ] and psychosocial disease [ 58 , 59 ], such as anxiety and depression [ 60 ]. Side effects following the administration of therapies may vary according to the type of disease, the type and duration of the treatment, the age of patients and their socio-economic situation.…”

Section: Discussionmentioning

confidence: 99%

A protocol to isolate and qualify purified human preantral follicles in cases of acute leukemia, for future clinical applications

et al. 2018

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BackgroundAutotransplantation of cryopreserved ovarian cortex can be associated with a risk of cancer cell reseeding. This issue could be eliminated by grafting isolated preantral follicles. Collagenase NB6 is an enzyme produced under good manufacturing practices (GMP) in compliance with requirements for tissue engineering and transplantation in humans and thus can be used to isolate preantral follicles from ovarian tissue in the framework of further clinical applications. Multicolor flow cytometry is an effective tool to evaluate the potential contamination of follicular suspensions by leukemic cells.MethodsThe efficiency of collagenase NB6 was evaluated in comparison to collagenase type IA and Liberase DH, in terms of yield, morphology and viability. A short-term in vitro culture of follicles isolated with collagenase NB6 was conducted for 3 days in a fibrin matrix. A modelization procedure was carried out to detect the presence of leukemic cells in follicular suspensions using multicolor flow cytometry (MFC).ResultsNo statistical differences were found between collagenase NB6, Liberase DH (p = 0.386) and collagenase type IA (p = 0.171) regarding the number of human preantral follicles isolated. The mean diameter of isolated follicles was significantly lower with collagenase NB6 (p < 0.0001). The survival rate of isolated follicles was 93.4% (n = 272) using collagenase NB6 versus 94.9% (n = 198) with Liberase DH and 92.6% (n = 298) using collagenase type IA. Even after 3 days of in vitro culture in a fibrin scaffold, most of the isolated follicles were still alive after using collagenase NB6 (90.7% of viable follicles; n = 339). The rate of isolated Ki67-positive follicles was 29 ± 9.19% before culture and 45 ± 1.41% after 3 days. In 23 out of 24 follicular suspensions analyzed, the detection of leukemic cells by MFC was negative. The purification had no significant impact on follicle viability.ConclusionThe isolation and purification of human preantral follicles were performed following good manufacturing practices for cell therapy. Multicolor flow cytometry was able to confirm that final follicular suspensions were free from leukemic cells. This safe isolation technique using collagenase NB6 can be considered for future clinical applications.

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Section: Discussionmentioning

confidence: 99%

A protocol to isolate and qualify purified human preantral follicles in cases of acute leukemia, for future clinical applications

et al. 2018

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“…The diagnosis of a gynaecological cancer is a very stressful experience for women with a significant impact on their psychological, sexual and social functioning [ 1 , 2 , 15 , 16 ]. Women with gynaecological cancer suffer from depression, anxiety, suicidal ideation, feelings of anger and shame, lower self-esteem and a poor quality of life (QoL) [ 1 , 2 , 15 – 19 ].…”

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confidence: 99%

Psychological impact of fertility preservation techniques in women with gynaecological cancer

Laganà¹,

Rosa²,

Rapisarda³

et al. 2017

ecancer

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Gynaecological cancer is a very stressful experience for women and treatments can compromise fertility and reproductive capacity. Fertility preservation techniques in women with gynaecological cancer can play an important role in improving the quality of life of these patients but, in many cases, the information about this type of treatment is not adequate. It is important to further investigate this topic in order to reduce the impact of gynaecological cancer on the quality of life of survivors as much as possible.

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“…However, we need to collect and analyze clinicopathological data, in order to formulate a standard for the management of fertility preservation surgery in reproductive-aged patients with stage I ovarian LCNEC. Based on recent research, cancer is known to influence survivors’ sexual function, motivation for childbearing and partner-related fears [62, 63]. A multidisciplinary team including oncology and reproductive endocrinology providers, as well as good communication between the team and psychosocial supporters about fertility preservation, is critical for women who undergo gonadotoxic treatments [56, 64].…”

Section: Discussionmentioning

confidence: 99%

Pathological features, clinical presentations and prognostic factors of ovarian large cell neuroendocrine carcinoma: a case report and review of published literature

2019

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Background There is no consensus on the optimal chemotherapy regimen and the prognostic factors for ovarian large cell neuroendocrine carcinoma (LCNEC), a rare type of tumor. The objective of the present study is to present the case of a recent encounter of pure ovarian LCNEC and perform a brief review to summarize the clinicopathological features and prognostic factors of 57 cases of LCNEC patients that have been previously reported. Method: case presentation Eligible studies were searched for online and 57 cases with clear follow-up data were found to have been reported. We present the 58th case, which is of a 70-year-old woman with stage IIIc primary pure LCNEC of the ovary. The initial symptom of this patient was abdominal distension (more than 2 months). A recent ultrasound test showed a solid-cystic mass occupying the pelvic and abdominal cavity. She received two courses of cisplatin-etoposide chemotherapy as an adjuvant therapy. No signs of nonclinical or radiological evidence of disease recurrence was found at follow-up examinations during the first 3 months after operation. A retrospective review of these 58 cases was conducted and survival curves were estimated. Using the Kaplan-Meier method. Conclusion The patients included were aged between 18 and 80 years. A Kaplan-Meier survival curve revealed that the median overall survival was 10.000 months, while 26 (44.83%) patients died within 12 months. We compared the overall mean survival time of all patients with that of stage I patients (42.418 vs 42.047 months), which suggests that ovarian LCNEC has a very poor prognosis even at stage I. Mean survival was longer for patients who had undergone postoperative chemotherapy than for those without postoperative chemotherapy (48.082 vs 9.778 months). A small series, such as this, does not provide adequate data to establish a firm correlation between the postoperative chemotherapy and prognosis ( p = 0.176). In our review of 58 cases with ovarian LCNEC, prognosis was unfavorable in most cases. Given the rarity of LCNEC, it is highly recommended that a global medical database of ovarian LCNEC and a standard system of diagnosis and treatment is established.

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Comment on: “The consequences of gynaecological cancer in patients and their partners from the sexual and psychological perspective”

Cited by 14 publications

References 9 publications

A protocol to isolate and qualify purified human preantral follicles in cases of acute leukemia, for future clinical applications

A protocol to isolate and qualify purified human preantral follicles in cases of acute leukemia, for future clinical applications

Psychological impact of fertility preservation techniques in women with gynaecological cancer

Pathological features, clinical presentations and prognostic factors of ovarian large cell neuroendocrine carcinoma: a case report and review of published literature

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