Comment on “The application of Ozone in dentistry: A systematic review of the literature”

Lynch, Edward

doi:10.1016/j.jdent.2008.11.002

Cited by 21 publications

(14 citation statements)

References 32 publications

(31 reference statements)

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“…The aim of this study was to evaluate the efficacy of ozone therapy but not as a new chemical solution that would substitute any component of the protocol. Thus, in this sense, these results confirm Lynch’s statement that ozone is most effective after traditional cleaning, shaping, and irrigation has been completed 15 .…”

Section: Discussionsupporting

confidence: 87%

“…Singlet oxygen, hydrogen peroxide, and superoxide anions oxidate the polyunsaturated fatty acid of the bacterial cell wall membrane provoking the disruption of the bacterial membrane 2 , 10 , 13 , 15 , 19 .…”

Section: Discussionmentioning

confidence: 99%

“…In parallel, ozone increases the production of adenosine triphosphate (ATP) by mitochondria, which leads to a metabolic improvement and to healing of inflammatory/infectious processes 1 , 2 , 4 , 8 , 11 , 15 , 17 , 19 .…”

Section: Introductionmentioning

confidence: 99%

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Ozone therapy as an adjuvant for endondontic protocols: microbiological – ex vivo study and citotoxicity analyses

Nogales¹,

Ferreira²,

MONTEMOR³

et al. 2016

J. Appl. Oral Sci.

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Objectives This study evaluated the antimicrobial efficacy of ozone therapy in teeth contaminated with Pseudomonas aeruginosa, Enterococcus faecalis, and Staphylococcus aureus using a mono-species biofilm model. Parallel to this, the study aimed to evaluate the cytotoxicity of ozone for human gingival fibroblasts. Material and Methods: One hundred and eighty single-root teeth were contaminated with a mono-species biofilm of Enterococcus faecalis, Pseudomonas aeruginosa, and Staphylococcus aureus. Groups were formed: Group I – control; Group II – standard protocol; Group III – standard protocol + ozone gas at 40 µg/mL; and Group IV – standard protocol + aqueous ozone at 8 µg/mL. In parallel, human gingival fibroblasts were submitted to the MTT test. Cells were plated, then ozone was applied as follows: Group I (control) – broth medium; Group II – aqueous ozone at 2 µg/mL; Group III – aqueous ozone at 5 µg/mL; and Group IV – aqueous ozone at 8 µg/mL. Data were submitted to the Kruskal Wallis test and Bonferroni post hoc analyses to assess microbiology and cytotoxicity, respectively (p<0.05%).Results The results revealed antimicrobial efficacy by Group IV with no CFU count. The cytotoxicity assay showed Groups III and IV to be the most aggressive, providing a decrease in cell viability at hour 0 from 100% to 77.3% and 68.6%, respectively. Such a decrease in cell viability was reverted, and after 72 hours Groups III and IV provided the greatest increase in cell viability, being statistically different from Groups I and II.Conclusion According to the applied methodology and the limitations of this study, it was possible to conclude that ozone therapy improved the decontamination of the root canal ex vivo. Ozone was toxic to the cells on first contact, but cell viability was recovered. Thus, these findings suggest that ozone might be useful to improve root canal results.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Ozone therapy as an adjuvant for endondontic protocols: microbiological – ex vivo study and citotoxicity analyses

Nogales¹,

Ferreira²,

MONTEMOR³

et al. 2016

J. Appl. Oral Sci.

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show abstract

“…This positive result contrasts with past work, which compared the efficacy of ozone with other antimicrobial agents using short-term broth cultures rather than biofilms (28,29). Past work has used very low doses of ozone (18), whereas the present study assessed the capability of ozone in terms of its antibacterial actions against an intact biofilm of E. faecalis under exposure conditions that more closely resemble those used in clinical practice.…”

Section: Discussioncontrasting

confidence: 69%

Treatment of Root Canal Biofilms of Enterococcus faecalis with Ozone Gas and Passive Ultrasound Activation

Case¹,

Bird²,

Kahler³

et al. 2012

Journal of Endodontics

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“…Recently, both gaseous and aqueous ozone have shown antimicrobial activities against the oral pathogens associated with caries, endodontic infections and periodontitis [16][17][18][19]. Moreover, ozonated water has been found to accelerate the healing of the oral mucosa following a tooth extraction process or after surgical interventions because the ozonated water is associated with a hemostatic action [20].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial effects of ozonated water on the sanitization of dental instruments contaminated with E. coli, S. aureus, C. albicans, or the spores of B. atrophaeus

César¹,

Sumita²,

Junqueira³

et al. 2012

Journal of Infection and Public Health

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Comment on “The application of Ozone in dentistry: A systematic review of the literature”

Cited by 21 publications

References 32 publications

Ozone therapy as an adjuvant for endondontic protocols: microbiological – ex vivo study and citotoxicity analyses

Ozone therapy as an adjuvant for endondontic protocols: microbiological – ex vivo study and citotoxicity analyses

Treatment of Root Canal Biofilms of Enterococcus faecalis with Ozone Gas and Passive Ultrasound Activation

Antimicrobial effects of ozonated water on the sanitization of dental instruments contaminated with E. coli, S. aureus, C. albicans, or the spores of B. atrophaeus

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