Comment on <scp>MDBGN</scp>/<scp>DBDCB</scp>, the European baseline series, and <scp>EU</scp> legislation

Lidén, Carola; White, Ian R.

doi:10.1111/cod.13937

Cited by 7 publications

(6 citation statements)

References 10 publications

(8 reference statements)

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“…Banned in cosmetics by the EU from 2007, 68 MDBGN may still be used in all product‐type 6 (PT6) categories (preservatives for products during storage). PT6 sub‐categories 69 are technical fluids, including washing and cleaning fluids, paints and coatings, metal working fluids and glues and adhesives. Labelling is not mandatory if concentration limits are not exceeding 0.1%.…”

Section: Discussionmentioning

confidence: 99%

“…Labelling is not mandatory if concentration limits are not exceeding 0.1%. Other possible exposures are medical devices and medicinal products, where MDBGN is permitted 69 …”

Section: Discussionmentioning

confidence: 99%

“…Due to the lack of full labelling of many products including technical and cleaning fluids, glues, adhesives and medical devices determining relevance of a sensitization as well as consecutive allergen avoidance is difficult. Legal regulations for full labelling are highly needed 15,69,70 …”

Section: Discussionmentioning

confidence: 99%

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Occupational contact allergy: The European perspective–Analysis of patch test data from ESSCA between 2011 and 2020

et al. 2023

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Background Occupational skin diseases have led the occupational disease statistics in Europe for many years. Especially occupational allergic contact dermatitis is associated with a poor prognosis and low healing rates leading to an enormous burden for the affected individual and for society. Objectives To present the sensitization frequencies to the most relevant allergens of the European baseline series in patients with occupational contact dermatitis (OCD) and to compare sensitization profiles of different occupations. Methods The data of 16 022 patients considered having OCD after patch testing within the European Surveillance System on Contact Allergies (ESSCA) network between January 2011 and December 2020 were evaluated. Patients (n = 46 652) in whom an occupational causation was refuted served as comparison group. Results The highest percentages of OCD were found among patients working in agriculture, fishery and related workers, metal industry, chemical industry, followed by building and construction industry, health care, food and service industry. Sensitizations to rubber chemicals (thiurams, carbamates, benzothiazoles) and epoxy resins were associated with at least a doubled risk of OCD. After a decline from 2014 onwards, the risks to acquire an occupation‐related sensitization to methyl(chloro)isothiazolinone (MCI/MI) and especially to methylisothiazolinone (MI) seem to increase again. Sensitization rates to formaldehyde were stable, and to methyldibromo glutaronitrile (MDBGN) slightly decreasing over time. Conclusions Among allergens in the European Baseline Series, occupational relevance is most frequently attributed to rubber accelerators, epoxy resins and preservatives.

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Section: Discussionmentioning

confidence: 99%

“…Labelling is not mandatory if concentration limits are not exceeding 0.1%. Other possible exposures are medical devices and medicinal products, where MDBGN is permitted 69 …”

Section: Discussionmentioning

confidence: 99%

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Occupational contact allergy: The European perspective–Analysis of patch test data from ESSCA between 2011 and 2020

et al. 2023

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“…Liden et al mentioned that although the MDBGN has been prohibited in cosmetics, it can be used in industrial products with undisclosed labels, which may cause an increased sensitization in the following timeline. 16,17 Since the 1980s, MCI/MI (trade name: Kathon CG) has been the second most commonly used preservative, at a ratio of 3:1. According to the ESSCA network's data, the prevalence of sensitization to MCI/MI 0.02% aq.…”

Section: Discussionmentioning

confidence: 99%

Increased rates of contact allergy to selected preservatives in patients with allergic contact dermatitis in Turkey

Sürgün,

Boyvat

2023

Contact Dermatitis

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BackgroundPreservatives are a frequent cause of allergic contact dermatitis (ACD) and have caused numerous epidemics.ObjectivesThe objective of this study is to determine the prevalence of preservative sensitivity, assess the change in the frequency of sensitivity, identify new preservatives with increased sensitivity rates, and evaluate the situation in Turkey by comparing our findings with current literature.MethodsA total of 201 patients diagnosed with ACD between 2018 and 2020, were patch tested with the European baseline series and additional seven preservative haptens. The change in the prevalence of sensitivity to each preservative hapten was investigated by comparing the data from the study conducted in our department between 2000 and 2004.ResultsResults showed that 17.4% (n = 35) of the patients were positive for preservatives. Comparison with previous data from 2000 to 2004 revealed an increase in the frequency of sensitization. The most prevalent allergen was methyldibromo glutaronitrile (9.5%), followed by methylchloroisothiazolinone/methylisothiazolinone (6.5%), and methylisothiazolinone (5%).ConclusionThe increase in preservative sensitivity in Turkey is the most remarkable finding. Although MDBGN was prohibited in cosmetic products, MCI/MI and MI are still widely used. Our findings suggest that awareness of preservative sensitivity should be increased and additional precautions should be taken, also in Turkey, regarding the use of preservatives.

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“…To the Editor, We would like to thank Lidén and White for their "Comment on MDBGN/DBDCB, the European baseline series, and EU legislation" 1 regarding our publication 2 and their thorough and accurate review about legislation concerning methyldibromo glutaronitrile (MDBGN) in Europe. We are aware that the information about the current status of legislation was not provided in our article; however, such a type of review was beyond the scope of our research.…”

mentioning

confidence: 99%

Arguments in favour of excluding MDBGN from the European baseline series. In response to “Comment on MDBGN/DBDCB, the European baseline series, and EU legislation”

et al. 2021

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Comment on MDBGN/DBDCB, the European baseline series, and EU legislation

Cited by 7 publications

References 10 publications

Occupational contact allergy: The European perspective–Analysis of patch test data from ESSCA between 2011 and 2020

Occupational contact allergy: The European perspective–Analysis of patch test data from ESSCA between 2011 and 2020

Increased rates of contact allergy to selected preservatives in patients with allergic contact dermatitis in Turkey

Arguments in favour of excluding MDBGN from the European baseline series. In response to “Comment on MDBGN/DBDCB, the European baseline series, and EU legislation”

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