Comment on: Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats

Rafieian-Kopaei, Mahmoud; Nasri, Hamid

doi:10.12659/msmbr.889344

Cited by 28 publications

(3 citation statements)

References 12 publications

(8 reference statements)

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“…The high dose of the extract also increased total thiol concentration in hippocampal tissues. In contrast to the beneficial effects of Teucrium polium which were mentioned and were seen in the present study, hepatotoxic and nephrotoxic effects of the plant have also been reported [ 62 ] and should be considered before reaching a final conclusion about the utility of this plant.…”

Section: Discussioncontrasting

confidence: 55%

Beneficial Effects ofTeucrium poliumand Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats

Mousavi

Niazmand

Hosseini

et al. 2015

International Journal of Alzheimer's Disease

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Objective. The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated. Methods. The rats were divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) Diabetic-Extract 200 (Dia-Ext 200), (5) Diabetic-Extract 400 (Dia-Ext 400), and (6) Diabetic-Metformin (Dia-Met). Groups 3–6 were treated by 100, 200, and 400 mg/kg of the extract or metformin, respectively, for 6 weeks (orally). Results. In passive avoidance test, the latency to enter the dark compartment in Diabetic group was lower than that of Control group (P < 0.01). In Dia-Ext 100, Dia-Ext 200, and Dia-Ext 400 and Metformin groups, the latencies were higher than those of Diabetic group (P < 0.01). Lipid peroxides levels (reported as malondialdehyde, MDA, concentration) in the brain of Diabetic group were higher than Control (P < 0.001). Treatment by all doses of the extract and metformin decreased the MDA concentration (P < 0.01). Conclusions. The results of present study showed that metformin and the hydroalcoholic extract of Teucrium polium prevent diabetes-induced memory deficits in rats. Protection against brain tissues oxidative damage might have a role in the beneficial effects of the extract and metformin.

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Section: Discussioncontrasting

confidence: 55%

Beneficial Effects ofTeucrium poliumand Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats

Mousavi

Niazmand

Hosseini

et al. 2015

International Journal of Alzheimer's Disease

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“…Teucrium polium ( T. polium ) is a flowering plant native to Europe, North Africa, and Southwest Asia[ 161 ]. T. polium has been used to treat diabetes, rheumatologic diseases, inflammation, and gastrointestinal disorders[ 162 , 163 ].…”

Section: Discussionmentioning

confidence: 99%

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Narzary¹,

Swarnakar²,

Kalita³

et al. 2023

World J Clin Cases

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BACKGROUND Diabetic foot ulcer (DFU) is a serious health issue of diabetes mellitus that affects innumerable people worldwide. Management and treatment of this complication are challenging, especially for those whose immune system is weak. AIM To discuss the plants and their parts used to heal DFU, along with the mode of their administration in diabetic patients. METHODS The original articles on “the plants for the treatment of DFU” studied in clinical cases only were obtained from various bibliographic databases using different keywords. RESULTS The search resulted in 22 clinical cases records with 20 medicinal plants belonging to 17 families on 1553 subjects. The fruits and leaves were the most preferentially used parts for DFU treatment, regardless of whether they were being administered orally or applied topically. Of the 20 medicinal plants, 19 reported their effectiveness in increasing angiogenesis, epithelialization, and granulation, thus hastening the wound-healing process. The efficacy of these botanicals might be attributed to their major bioactive compounds, such as actinidin and ascorbic acid (in Actinidia deliciosa ), 7-O-(β-D-glucopyranosyl)-galactin (in Ageratina pichinchensis ), omega-3-fatty acid (in Linum usitatissimum ), isoquercetin (in Melilotus officinalis ), anthocyanins (in Myrtus communis ), and plantamajoside (in Plantago major ). CONCLUSION The validation of mechanisms of action underlying these phytocompounds contributing to the management of DFU can aid in our better understanding of creating efficient treatment options for DFU and its associated problems.

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“…It should be noted that herbal medicines usually have low intensity side effects and, sometimes, are even used to combat the toxicity of toxic materials (3,(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52). However, the plants and their products may induce hazardous adverse effects, too (50,(53)(54)(55)(56)(57). Therefore, long-term observational trials should be conducted in order to confirm the medicinal effects attributed to this plant and its safety profile.…”

Section: Discussionmentioning

confidence: 99%

Remedial Effect of Boswellia Serrata on Thermal Burn Injuries

et al. 2015

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Background:It has been shown that inflammation and insufficient blood vessel formation delay wound healing, whereas Boswellia serrata, besides anti-inflammatory activity, increases blood vessel formation. Objectives: This study was performed to investigate the effect of Boswellia serrata in promoting burn injuries healing in BALB/c mice. Materials and Methods:In this experimental study, a burn wound was created by placing a 1.5 cm 2 hot plate on the back of animals. Fifty four mice were designated in four equal groups, counting 14 each. Three groups of animals were treated with Boswellia 2%, silver sulfadiazine and vaseline two times per day for 21 days. The fourth group represented the control group. The total percentage of wound healing and time required for complete healing were evaluated and compared between groups, using the ANOVA test. Results: Results showed that the effect of Boswellia on wound healing was statistically significant compared to the control group (P < 0.01). Conclusions: Boswellia serrata is clearly effective for burn injuries healing and might be used in patients with burn wound.

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Comment on: Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats

Cited by 28 publications

References 12 publications

Beneficial Effects ofTeucrium poliumand Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats

Beneficial Effects ofTeucrium poliumand Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Remedial Effect of Boswellia Serrata on Thermal Burn Injuries

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Comment on: Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats

Cited by 28 publications

References 12 publications

Beneficial Effects ofTeucrium poliumand Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats

Beneficial Effects ofTeucrium poliumand Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review

Remedial Effect of Boswellia Serrata on Thermal Burn Injuries

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Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review