Comment on pediatric living donor liver transplantation decade progress in Shanghai: Characteristics and risks factors of mortality

Akbulut, Sami; Sahin, Tevfik Tolga; Yilmaz, Sezai

doi:10.3748/wjg.v26.i30.4564

Cited by 16 publications

(11 citation statements)

References 9 publications

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“…Univariate analysis was used to evaluate the factors associated with negative appendectomy. The parameters that had P < 0.2 from the univariate analysis were selected for the multivariate logistic regression model with backward elimination [ 19 ]. Logistic regression was used to measure the relationship between dependent variables and one or more than independents variables with a Mann–Whitney U-test or Kruskal–Wallis test.…”

Section: Methodsmentioning

confidence: 99%

Negative appendectomy rate in patients diagnosed with acute appendicitis

2022

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Background Acute appendicitis is the most common cause of acute lower abdominal pain leading patients to the emergency department. This study aims to find the negative appendectomy rate in patients diagnosed with acute appendicitis from 2015 to 2019. Methods This study was a retrospective cohort study in the patients preoperatively diagnosed with acute appendicitis and underwent appendectomy from January 2015 to December 2019. Negative appendectomy is defined as the final pathologic results confirmed normal, congestion or peri-appendicitis. Results The study population was 892 patients which was 54.3% female. The five-year negative appendectomy rate was 8.6% (n = 77) and 70% in female (n = 54). The factors associated with increasing the negative appendectomy rate were female (OR 2.23, P = 0.003), age ≤ 40 years old (OR 2.35, P = 0.003), and no history of diarrhea (OR 2.42, P = 0.017). Whereas the factors related to decline in the negative appendectomy rate were white blood cell count (WBC) $$\ge$$ ≥ 10,000 (OR 0.39, P = 0.016), neutrophil (N) $$\ge$$ ≥ 75% (OR 0.28, P < 0.001), and positive appendicitis from ultrasonography of abdomen (OR 0.04, P < 0.001) or computed tomography of abdomen (OR 0.07, P < 0.001). Conclusion The negative appendectomy rate was less than 10% in this study. Female, age 40 ≤ years old and history of diarrhea were related to increase in negative appendectomy. The factors that related to decline in negative appendectomy were leukocytosis with cells shift to the left, positive acute appendicitis from abdominal ultrasonography and CT scan. However, to request the further imaging studies to diagnose patients with suspected acute appendicitis depends on the risk and benefit to each patient and the choice of investigation.

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Section: Methodsmentioning

confidence: 99%

Negative appendectomy rate in patients diagnosed with acute appendicitis

2022

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“…Comparisons were expressed by the Mann–Whitney U -test for continuous variables and the Chi-square test for categorical variables as appropriate. The PNF was analyzed using the univariate analysis, and variables significant at a p < 0.20 in the univariate analysis were used in the multivariate logistic regression model ( 15 ). Graft survival was estimated by the Kaplan–Meier method and differences in survival between the two groups were compared with the log-rank test.…”

Section: Methodsmentioning

confidence: 99%

Liver Graft-to-Spleen Volume Ratio as a Useful Predictive Factor of the Outcomes in Living Donor Liver Transplantation: A Retrospective Study

Xiao

Lin

et al. 2022

Front. Surg.

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BackgroundIn living donor liver transplantation (LDLT), graft-to-recipient weight ratio (GRWR) <0. 8% is an important index for predicted portal hypertension, which may induce the graft small-for-size syndrome (SFSS). Recently, the value of graft-to-spleen volume ratio (GSVR) on predicted portal hypertension had been reported, whether without splenectomy prevent portal hypertension in transplantation remains disputed, we aimed to identify GSVR contributing to portal venous pressure (PVP) and outcomes without simultaneous splenectomy in LDLT.MethodsA retrospective study had been designed. Excluded patients with splenectomy, 246 recipients with LDLT between 2016 and 2020 were categorized into a low GSVR group and a normal GSVR group. Preoperative, intraoperative, and postoperative data were collected, then we explored different GSVR values contributing to portal hypertension after reperfusion.ResultsAccording to the first quartile of the distributed data, two groups were divided: low GSVR (<1.03 g/mL) and normal GSVR (>1.03 g/mL). For the donors, there were significant differences in donor age, graft type, liver size, GRWR, and GSVR (P < 0.05). Following the surgical factors, there were significant differences in blood loss and CRBC transfusion (P < 0.05). The low GSVR has demonstrated had a significant relationship with ascites drainage and portal venous flow after LDLT (P < 0.05). Meanwhile, low GSVR heralds worse results which covered platelet count, international normalized ratio (INR), and portal venous velocity. Kaplan–Meier analysis showed that there was a significant difference between the two groups, while the low GSVR group demonstrated worse recipients survival compared with the normal GSVR group (P < 0.05).ConclusionsWithout splenectomy, low GSVR was an important predictor of portal hypertension and impaired graft function after LDLT.

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“…The distribution of fatigue among demographic and clinical characteristics was analyzed with non-parametric tests. According to the univariate analysis ( p < 0.10) and clinical relevance ( Akbulut et al, 2020 ), seven variables were selected as control variables in the multivariate hierarchical model. Correlations betwen social support, social functioning, and fatigue were calculated using Spearman correlations.…”

Section: Methodsmentioning

confidence: 99%

The mediating effect of social functioning on the relationship between social support and fatigue in middle-aged and young recipients with liver transplant in China

Zhang

Wei

2022

Front. Psychol.

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ObjectiveThe objective of the study was to explore the relationship between social support and fatigue as well as the mediating role of social functioning on that relationship.BackgroundPsychosocial factors such as social support and social functioning may influence patients’ fatigue symptoms. There is limited evidence on the relationship between social support, social functioning, and fatigue in liver transplant recipients.MethodsA total of 210 patients with liver transplants from two tertiary hospitals were enrolled in the current study. Questionnaires used include one for general demographic data, the Perceived Social Support Scale (PSSS), Social Disability Screening Schedule (SDSS), and Fatigue Symptom Inventory (FSI).ResultsA total of 126 (60%) recipients reported fatigue. Gender, residence, BMI, and liver function were the primary factors affecting fatigue. Social support was positively correlated with social functioning and was negatively correlated with fatigue. The effect of social support on fatigue was partially mediated by social functioning (35.74%).ConclusionThe fatigue of liver transplant recipients should be attended to. The higher the social support, the lower the fatigue of liver transplant recipients. Social support may also reduce fatigue through social functioning. The liver transplant team should help the liver transplant recipient establish a social support system, restore social functioning, and reduce fatigue symptoms.

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Comment on pediatric living donor liver transplantation decade progress in Shanghai: Characteristics and risks factors of mortality

Cited by 16 publications

References 9 publications

Negative appendectomy rate in patients diagnosed with acute appendicitis

Negative appendectomy rate in patients diagnosed with acute appendicitis

Liver Graft-to-Spleen Volume Ratio as a Useful Predictive Factor of the Outcomes in Living Donor Liver Transplantation: A Retrospective Study

The mediating effect of social functioning on the relationship between social support and fatigue in middle-aged and young recipients with liver transplant in China

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