Comment on “Multiple repressive mechanisms in the hippocampus during memory formation”

Mathew, Rebecca; Mullan, Hillary; Blusztajn, Jan Krzysztof; Lehtinen, Maria K.

doi:10.1126/science.aaf1288

Cited by 15 publications

(16 citation statements)

References 13 publications

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“…Interplay between CSF Composition and Brain Function in the Context of Stress, Disease, and Neurodevelopmental Disorders Following stress induced by contextual fear conditioning, expression of ChP genes is dramatically suppressed, in some cases to a greater degree than in the adjacent hippocampus (Cho et al, 2015;Mathew et al, 2016). Such changes have the potential to alter learning and memory via differential exchange of blood-borne signals between the CSF, removal of other signals, as well as changes in ChP secretion of plasticity-related signals into the CSF.…”

Section: Development Of Chp Immune Functionsmentioning

confidence: 99%

Emergence and Developmental Roles of the Cerebrospinal Fluid System

2020

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We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS component with dynamic and diverse roles emerging in parallel with the developing CNS. This review examines the current understanding about early CSF and its maturation and roles during CNS development and discusses open questions in the field. We focus on developmental changes in the ventricular system and CSF sources (including neural progenitors and choroid plexus). We also discuss concepts related to the development of fluid dynamics including flow, perivascular transport, drainage, and barriers.

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Section: Development Of Chp Immune Functionsmentioning

confidence: 99%

Emergence and Developmental Roles of the Cerebrospinal Fluid System

2020

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“…It is noteworthy that it has been recently reported that the CP might be, at least partially, involved in the contextual fear-learning as it exhibits, in some instances, stronger response to stressful stimuli at the levels of gene transcription as compared to the hippocampus. Altered expression of multiple genes encoding secreted molecules such as the putative hormone augurin represent an example [72,73]. Recently, the CP has been also implicated as an entry site for various hormones produced in response to changed physiological state that are present in the blood, thus directly affecting their availability in the brain.…”

Section: The Choroid Plexus-key Regulator Of Csf Productionmentioning

confidence: 99%

Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS

Kaiser

Bryja

2020

IJMS

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Cerebrospinal fluid (CSF) is the liquid that fills the brain ventricles. CSF represents not only a mechanical brain protection but also a rich source of signalling factors modulating diverse processes during brain development and adulthood. The choroid plexus (CP) is a major source of CSF and as such it has recently emerged as an important mediator of extracellular signalling within the brain. Growing interest in the CP revealed its capacity to release a broad variety of bioactive molecules that, via CSF, regulate processes across the whole central nervous system (CNS). Moreover, CP has been also recognized as a sensor, responding to altered composition of CSF associated with changes in the patterns of CNS activity. In this review, we summarize the recent advances in our understanding of the CP as a signalling centre that mediates long-range communication in the CNS. By providing a detailed account of the CP secretory repertoire, we describe how the CP contributes to the regulation of the extracellular environment—in the context of both the embryonal as well as the adult CNS. We highlight the role of the CP as an important regulator of CNS function that acts via CSF-mediated signalling. Further studies of CP–CSF signalling hold the potential to provide key insights into the biology of the CNS, with implications for better understanding and treatment of neuropathological conditions.

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“…First, it enriches for cell type-specific translational changes, reducing the problem of heterogeneity of gene expression changes in response to a physiologically relevant stimulus. Second, TRiP improves reproducibility across samples as it is insensitive to imprecise dissection, a problem that can produce misleading results (Mathew et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Experience-dependent translational state defined by cell type-specific ribosome profiling

Eacker

Crawford

Brichta

et al. 2017

Preprint

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Experience-dependent neuronal activity regulates the translation of mRNA, supporting memory formation. We have developed a new method termed translating ribosome affinity purification and ribosome profiling (TRiP) which allows us to determine cell typespecific ribosome occupancy of mRNA with nucleotide resolution. Using TRiP we show that a memory-inducing experience creates a distinct translational state in mouse CA1 pyramidal cells. The experience-dependent translation state is characterized by enhanced translation of protein-coding open reading frames (ORFs) including numerous components of the actin cytoskeleton and calcium/calmodulin binding proteins, and by decreased translation of a defined subset of genes containing upstream ORFs (uORFs).Using animals heterozygous for an unphosphorylatable allele of the eukaryotic translation initiation factor 2α (eIF2α), we show that dephosphorylation of eIF2α contributes significantly to the experience-dependent translation state. These observations demonstrate that TRiP is a valuable methodology for studying physiologically relevant changes in translational state in genetically defined cell types.

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Comment on “Multiple repressive mechanisms in the hippocampus during memory formation”

Cited by 15 publications

References 13 publications

Emergence and Developmental Roles of the Cerebrospinal Fluid System

Emergence and Developmental Roles of the Cerebrospinal Fluid System

Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS

Experience-dependent translational state defined by cell type-specific ribosome profiling

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