“…In conclusion, it is the basis for further analysis, such as signaling pathway enrichment, to use optimal statistical approaches ( Chrominski and Tkacz, 2015 ) and obtain accurate and convincing results of DEGs. We are looking forward to receiving further explanations about the data analysis from the authors and believe these considerations and innovations in data analytical and statistical approaches would benefit the data-intensive transcriptomics research ( Liu et al, 2021 ).…”