Comment on “Lung Transplantation for Elderly Patients With End-stage COVID–19 Pneumonia”

Baquero, A; Beyda, David H.; Gilcrease, Glynn Weldon; Gutierrez, Joseph E; Lavee, Jacob; Matas, David; Paul, Norbert W.; Richards, Bernadette; Robertson, Matthew P.; Rogers, Wendy; Scalettar, Raymond; Shapiro, Michael; Sharif, Adnan; Toledo, Alexander H.; Trey, Torsten

doi:10.1097/sla.0000000000004413

Cited by 2 publications

(1 citation statement)

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“…A total of 140 articles were identified, of which 87 remained after removal of duplicates, 31 underwent full-text review, and 27 were included (Figure 2). The 27 studies included 11 original manuscripts, 8-18 5 reviews/commentaries, 19-23 and 11 gray literature reports. 24-34 Article details are included in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Lung Transplantation for Severe Post–coronavirus Disease 2019 Respiratory Failure

et al. 2021

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Background. The coronavirus disease 2019 (COVID-19) pandemic has resulted in >72 million cases and 1.6 million deaths. End-stage lung disease from COVID-19 is a new and growing entity that may benefit from lung transplant; however, there are limited data on the patient selection, perioperative management, and expected outcomes of transplantation for this indication. Methods. A systematic review of the literature was performed with searches of MEDLINE and Web of Science databases as well as the gray literature. All manuscripts, editorials, commentaries, and gray literature reports of lung transplantation for COVID-related respiratory failure were included. A case from the University of Virginia is described and included in the review. Results. A total of 27 studies were included: 11 manuscripts, 5 commentaries, and 11 gray literature reports. The total number of transplantations for COVID-related lung disease was 21. The mean age was 55±12 years, 16 (76%) were male individuals, and the acuity was high, with 85% on extracorporeal membrane oxygenation preoperatively. There was a 95% early survival rate, with 1 additional late death. There is growing histopathologic evidence for permanent structural damage with no replicating virus at the time of transplantation. Conclusions. Bilateral lung transplantation is an effective treatment option with reasonable short-term outcomes for patients with end-stage lung failure secondary to COVID-19. However, specific considerations in this new population require a multidisciplinary approach. As we move into the second wave of the COVID-19 global pandemic, lung transplantation will likely have a growing role in management of these complex patients.

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Section: Resultsmentioning

confidence: 99%