Sometimes it becomes a matter of natural choice for an observer (A) that he prefers a coordinate system of two-dimensional spatial x-y coordinates from which he observes another observer (B) who is moving at a uniform speed along a line of motion, which is not collinear with A's chosen x or y axis. It becomes necessary in such cases to develop Lorentz transformations where the line of motion is not aligned with either the x or the yaxis. In this paper we develop these transformations and show that under such transformations, two orthogonal systems (in their respective frames) appear nonorthogonal to each other. We also illustrate the usefulness of the transformation by applying it to three problems including the rod-slot problem. The derivation has been done before using vector algebra. Such derivations assume that the axes of K and K' are parallel. Our method uses matrix algebra and shows that the axes of K and K' do not remain parallel, and in fact K and K' which are properly orthogonal are observed to be non-orthogonal by K' and K respectively.