Comment on “Gold Nanoshells Improve Single Nanoparticle Molecular Sensors”

Jz, Zhang; Schwartzberg, Adam M.; Norman, Thaddeus J.; Cd, Grant; Liu, Jing; Bridges, F.; Buuren, T. van

doi:10.1021/nl0479379

Cited by 54 publications

(50 citation statements)

References 12 publications

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“…One example is the distinction between "coreshell" structures versus aggregates in the case of gold nanostructures from the reaction of HAuCl 4 and Na 2 S. [15,89] While the initial and several follow-up reports claimed Au 2 S-Au core-shell structure based primarily on spectroscopic data [90,91], more detailed studies based on a combination of spectroscopic, microscopy, and X-ray techniques have shown that the reaction product is mostly aggregates of gold nanoparticles. [15,33,92] This example shows that care must be exercised in structural determination that often requires a combination of techniques including high-resolution microscopy.…”

Section: Structure and Characterizationmentioning

confidence: 98%

Plasmonic Optical Properties and Applications of Metal Nanostructures

2008

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In this review article, we provide an overview of recent research activities in the study of plasmonic optical properties of metal nanostructures with emphasis on understanding the relation between surface plasmon absorption and structure. Both experimental results and theoretical calculations have indicated that the plasmonic absorption strongly depends on the detailed structure of the nanomaterials. Examples discussed include spherical nanoparticles, nanorods, nanowires, hollow nanospheres, aggregates, and nanocages. Plasmon-phonon coupling measured from dynamic studies as a function of particle size, shape, and aggregation state is also reviewed. The fascinating optical properties of metal nanostructures find important applications in a number of technological areas including surface plasmon resonance, surface-enhanced Raman scattering, and photothermal imaging and therapy. Their novel optical properties and emerging applications are illustrated using specific examples from recent literature. The case of hollow nanosphere structures is highlighted to illustrate their unique features and advantages for some of these applications.

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Section: Structure and Characterizationmentioning

confidence: 98%

Plasmonic Optical Properties and Applications of Metal Nanostructures

2008

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“…2 Ultimately the core-shell NP model fits experimental data, and additionally X-ray diffraction has indicated the presence of a gold-sulfide composite core with a continuous gold surface. 71,78,105 GGS NPs for therapeutic and imaging applications are generally synthesized in the range of 35-55 nm in diameter with a SPR near 800-900 nm, compared to gold silica nanoshells which range from 120 to 140 nm for the same resonant wavelength. 2 This size difference may prove advantageous, as models have suggested that particles with diameter <100 nm will move closer to the endothelium layer, potentially improving tumor extravasation 16 and experimental data suggests that peak gold uptake occurs for diameters between 30 and 50 nm.…”

Section: Gold Gold-sulfide Nanoparticlesmentioning

confidence: 99%

Tunable Nanostructures as Photothermal Theranostic Agents

2011

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The theranostic potential of several nanostructures has been discussed in the context of photothermal therapies and imaging. In the last several decades, the burden of cancer has grown rapidly, making the need for new theranostic approaches vital. Lasers have emerged as promising tools in cancer treatment, especially with the advent of photothermal therapies wherein light absorbing dyes or plasmonic gold nanoparticles are used to generate heat and achieve tumor damage. Recently, photoabsorbing nanostructures have materialized that can be employed in conjunction with lasers in the near-infrared region in order to enhance both imaging and photothermal effects. The incorporation of tunable nanostructures has resulted in improved specificity in cancer treatment. Silica-cored gold nanoshells and gold nanorods currently serve as the chief plasmonic structures for photothermal therapy. Although gold nanorods and silica-cored gold nanoshells have shown promise as therapeutic agents, over the past few years new nanostructures have emerged that offer comparable and even superior theranostic properties. In the present review, several theranostic agents and their impact on the development of more effective photothermal therapies for the treatment of cancer are discussed. These agents include hollow gold nanoshells, gold gold-sulfide nanoparticles, gold nanocages, carbon and titanium nanotubes, photothermal-based nanobubbles, polymeric nanoparticles and copper-based nanocrystals.

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“…Many attempts to synthesize "nanoshells" ended up with other structures, often aggregates. This has also been the origin of some debates in the literature [33,46,57] . Therefore, one must be careful when evaluating the literature about whether the acclaimed "nanoshells" are real or not.…”

Section: Pta Based On "Nanoshells"mentioning

confidence: 94%

“…As mentioned above, many acclaimed "nanoshells" are "shells" of aggregates [33,46,57] . Such structures are large in size (especially when a large silica particles are used as the core) and non-spherical in shape, show broad inhomogeneity in size and shape distribution, and have multiple dipolar modes and thereby board SPR absorption [34,35] .…”

Section: Pta Based On "Nanoshells"mentioning

confidence: 97%

Photothermal ablation therapy for cancer based on metal nanostructures

Rozanova

Zhang

2009

Sci. China Ser. B-Chem.

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Besides conventional surgery, radiation therapy, and chemotherapy, which all tend to have side-effects and damage normal tissues, new medical strategies, such as photothermal sensitization and photothermal ablation therapy (PTA) with near-IR laser light, have been explored for treating cancer. Much of the current excitement surrounding nanoscience is directly connected to the promise of new nanotechnology for cancer diagnosis and therapy. The basic principle behind PTA is that heat generated from light can be used to destroy cancer cells. Strong optical absorption and high efficiency of photothermal conversion at the cancer sites are critical to the success of PTA. Because of their unique optical properties, e.g., strong surface plasmon resonance (SPR) absorption, noble metal nanomaterials, such as gold and silver, have been found to significantly enhance photothermal conversion for PTA applications. Substantial effort has been made to develop metal nanostructures with optimal structural and photothermal properties. Ideal metal nanostructures should have strong and tunable SPR, be easy to deliver, have low toxicity, and be convenient for bioconjugation for actively targeting specific cancer cells. This review would highlight some gold nanostructures with various shapes and properties, including nanoparticles (NPs), nanorods (NRs), nanoshells, nanocages, and hollow nanospheres, which have been studied for PTA applications. Among these structures, hollow gold nanospheres (HGNs) exhibit arguably the best combined properties because of their small size (30-50 nm), spherical shape, and strong, narrow, and tunable SPR absorption.

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Comment on “Gold Nanoshells Improve Single Nanoparticle Molecular Sensors”

Cited by 54 publications

References 12 publications

Plasmonic Optical Properties and Applications of Metal Nanostructures

Plasmonic Optical Properties and Applications of Metal Nanostructures

Tunable Nanostructures as Photothermal Theranostic Agents

Photothermal ablation therapy for cancer based on metal nanostructures

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