Comment on “Extra-Intestinal Manifestations of Familial Adenomatous Polyposis”

Screening for Thyroid Cancer in Patients With Familial Adenomatous Polyposis

“…We would like to make some comments on the basis of our extensive experience on this subject. [2][3][4][5][6][7][8] We were the first to show, as Jarrar et al recognize, a significant genotype-phenotype correlation, suggesting that most of APC germline mutations in patients with FAPassociated PTC are located in a well-defined genomic area. [2][3][4] During the last decade, we have continued (1) to recruit FAP-associated PTC, (2) to follow up those previously collected, and (3) to collect all available data from the literature.…”

FAP associated cribriform morular variant of PTC: striking female prevalence and indolent course [Letter to the Editor]

“…FAP associated CMV-PTC, and to compare data from Ito's series with those from our large series of 18 subjects with FAP associated PTC, in order to detect similarities and differences. In 16 of 18 of our patients we detected the germ-line APC mutation, which was 5' to codon 1220 in 14 of 16 (the 2 remaining having mutations at codon 1309) [2][3][4].…”

Familial Adenomatous Polyposis-Associated Papillary Thyroid Carcinoma Shows an Indolent Course and Usually, but Not Always, Belongs to the Cribriform-Morular Variant of Papillary Thyroid Carcinoma

“…Finally, whereas in FAP subjects the femaleto-male ratio for colorectal cancer was 1: 1, there was a striking female prevalence (the F:M was 17: 1 in our original paper [2] and the F:M was 50: 1 in the subsequent review after year 2000 for FAP-associated PTC) [2][3][4] .…”

“…mutation [5] . In addition, whereas sporadic CMVPTCs could also occur in males aged more than 40 years and could also have a very aggressive behavior , FAP-associated PTCs always occur in females, usually before age 36, and almost always show an indolent course [2][3][4] .…”

“…In ad dition, there have been many reports of aggressive sporadic CVMPTC with distant metastasis, whereas there has been only 1 death because of thyroid-related complications out of 200 FAP-associated PTCs [2][3][4] .…”