Comment on “Anti-aging effects of ingenol mebutate for patients with actinic keratosis” and phenol-croton oil peelings

Wambier, Carlos Gustavo; Lee, Kachiu Cecilia; Bertolini, Thomas M.; Rullan, Peter P.; Beltrame, Flávio Luís

doi:10.1016/j.jaad.2019.01.065

Journal of the American Academy of Dermatology

2019

DOI: 10.1016/j.jaad.2019.01.065

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Comment on “Anti-aging effects of ingenol mebutate for patients with actinic keratosis” and phenol-croton oil peelings

Carlos Gustavo Wambier

Kachiu Cecilia Lee

Thomas M. Bertolini

et al.

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Cited by 3 publications

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References 7 publications

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“…We are pleased that Wambier et al 1 have provided additional commentary on our article linking phenol-croton oil peel to the application of topical ingenol mebutate, as both share similar essential phytochemical structures. As mentioned by Wambier et al, phenol-croton oil, which has chemical structures and enzymatic targets similar to those of ingenol mebutate, can eradicate mutated keratinocytes and reset follicular stem cells into basal layer cells.…”

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Reply to: “Comment on ‘Anti-aging effects of ingenol mebutate for patients with actinic keratosis' and phenol-croton oil peelings”

Kim

Jung

Kim

et al. 2019

Journal of the American Academy of Dermatology

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Reply to: “Comment on ‘Anti-aging effects of ingenol mebutate for patients with actinic keratosis' and phenol-croton oil peelings”

Kim

Jung

Kim

et al. 2019

Journal of the American Academy of Dermatology

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Advanced chemical peels: Phenol-croton oil peel

Wambier

Lee

Soon

et al. 2019

Journal of the American Academy of Dermatology

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Botany, traditional uses, phytochemistry, pharmacological and toxicological effects of Croton tiglium Linn.: a comprehensive review

Zhang

Liu

Sun

et al. 2022

Journal of Pharmacy and Pharmacology

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Objectives Croton tiglium Linn. (Euphorbiaceae) is an ancient medicinal plant that has been used for a long time, which is widely distributed in tropical and subtropical regions. And it is widely used for defecation, induced labour, treatment of gastrointestinal diseases, headache, as well as rheumatoid arthritis. Key findings Approximately 150 compounds have been isolated and identified from the seeds, stems, leaves and branches of C. tiglium, including fatty acids, terpenoids, alkaloids, the plants proteins and other types of components. Based on a wide range of biological properties, C. tiglium has a wide range of pharmacological effects, such as antitumor, anti-HIV, analgesic, anti-inflammatory and antibacterial effects. Summary The review aims to provide a critical and comprehensive evaluation of the botany, phytochemistry, pharmacology and toxicity of C. tiglium, with a vision for promoting further pharmaceutical research to explore its complete potential for better clinical application. The tigliane diterpenoids have been the most studied compounds isolated from C. tiglium, which showing a variety of biological activities, but there is insufficient evidence to explain the mechanism of action. In addition, C. tiglium may have potential toxic effects, and it is necessary to reduce the toxic effects to ensure the safety of clinical medication, which may promote the discovery and development of new drugs.

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Comment on “Anti-aging effects of ingenol mebutate for patients with actinic keratosis” and phenol-croton oil peelings

Cited by 3 publications

References 7 publications

Reply to: “Comment on ‘Anti-aging effects of ingenol mebutate for patients with actinic keratosis' and phenol-croton oil peelings”

Reply to: “Comment on ‘Anti-aging effects of ingenol mebutate for patients with actinic keratosis' and phenol-croton oil peelings”

Advanced chemical peels: Phenol-croton oil peel

Botany, traditional uses, phytochemistry, pharmacological and toxicological effects of Croton tiglium Linn.: a comprehensive review

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