Comment on Aasebø, E., et al. “The Progression of Acute Myeloid Leukemia from First Diagnosis to Chemoresistant Relapse: A Comparison of Proteomic and Phosphoproteomic Profiles”. Cancers 2020, 12, 1466

DeRosa, Peter; Nava, Victor E.

doi:10.3390/cancers12092461

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“…Also, genes directly involved in cell cycle control (CDK6) and soluble growth factors (HCF) had mutations in this tumor. Furthermore, trophic pathways related to surface receptors seem to be involved in our case, as suggested by mutations in CD36 (a lipid scavenger receptor) [14], LRP1B (a member of the low-density lipoprotein receptor family) [15] and FGFR2 (fibroblast growth factor receptor 2/CD332) [12]. Furthermore, additional epigenetic regulation may be represented by mutations in DNMT3A, a methyltransferase that may modulate gene expression by altering histones [16].…”

Section: Discussionmentioning

confidence: 82%

Novel Mutations in a Lethal Case of Lymphomatous Adult T Cell Lymphoma with Cryptic Myocardial Involvement

et al. 2021

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The autopsy of a 65-year-old diabetic African American male revealed significant left myocardial involvement by adult T-cell leukemia/lymphoma (ATLL) despite normal pre-mortem fluorodeoxyglucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT). Due to pre-existing diabetic cardiomyopathy with reduced ejection fraction (EF) and compatible imaging studies, cardiac lymphomatous involvement was not suspected. While peripheral blood was negative for leukemia, next-generation sequencing of a lymph node revealed at least eight novel mutations (AXIN1, R712Q, BARD1 R749K, CTNNB1 I315V, CUX1 P102T, DNMT3A S199R, FGFR2 S431L, LRP1B Y2560C and STAG2 I771M). These findings underscore a diagnostic pitfall in a rare lymphomatous variant of ATLL infiltrating myocardium and contribute to its molecular characterization.

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Section: Discussionmentioning

confidence: 82%

Novel Mutations in a Lethal Case of Lymphomatous Adult T Cell Lymphoma with Cryptic Myocardial Involvement

et al. 2021

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Comment on Aasebø, E., et al. “The Progression of Acute Myeloid Leukemia from First Diagnosis to Chemoresistant Relapse: A Comparison of Proteomic and Phosphoproteomic Profiles”. Cancers 2020, 12, 1466

Abstract: In a recent article published in this journal, Aasebø and colleagues reported [...]

Cited by 1 publication

References 4 publications

Novel Mutations in a Lethal Case of Lymphomatous Adult T Cell Lymphoma with Cryptic Myocardial Involvement

Novel Mutations in a Lethal Case of Lymphomatous Adult T Cell Lymphoma with Cryptic Myocardial Involvement

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