2017
DOI: 10.1172/jci95376
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Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation

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Cited by 63 publications
(84 citation statements)
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“…Consequently, Bifidobacterium depletion might contribute to the dysregulation of the immune system found in hypertensive l ‐NAME‐treated rats. In addition, increased Propionibacterium was also detected in gut microbiota from l ‐NAME group, which also influence intestinal immunity increasing Th17 population in MLN . However, our study did not clarify either the mechanisms involved in dysbiosis induced by NO synthesis inhibition or if changes in gut microbiota induced by l ‐NAME are involved in the raise of BP.…”
Section: Discussionmentioning
confidence: 57%
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“…Consequently, Bifidobacterium depletion might contribute to the dysregulation of the immune system found in hypertensive l ‐NAME‐treated rats. In addition, increased Propionibacterium was also detected in gut microbiota from l ‐NAME group, which also influence intestinal immunity increasing Th17 population in MLN . However, our study did not clarify either the mechanisms involved in dysbiosis induced by NO synthesis inhibition or if changes in gut microbiota induced by l ‐NAME are involved in the raise of BP.…”
Section: Discussionmentioning
confidence: 57%
“…By preventing barrier compromise LC40 treatment may reduce activation and migration of APC to the MLN, hence suppressing IL‐6 production and allowing for Treg to produce IL‐10, and reducing Th17 to produce IL‐17a. In addition, dihydrolipoamide acetyltransferase, one of the major proteins found in bacterial surface layer of Propionibacterium , has been described to stimulate intestinal APC, leading to T cell activation and Th17 differentiation . The reduction of Propionibacterium count in the gut microbiota induced by LC40 treatment might be involved in the lesser Th17 population found in MLN from l ‐NAME–LC40 group, as a result of inhibition of this pathway.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, Bifidobacterium , Faecalibacterium , Ruminococcus , and Prevotella were inversely related to low‐grade mucosal inflammation . Propionibacterium mitigated intestinal inflammation via Th17 cell regulation, which contributed to mucosal homeostasis and disorders in SIBO state. As for microbial function, there were mainly increased activity in pathways like carbohydrate and lipid metabolism, amino acid and nucleic acid biosynthesis, which restricted nutrient transport and uptake .…”
Section: Discussionmentioning
confidence: 99%
“…As JS22 was shown to lack the evolutionary counterpart for SlpB (Deptula et al, 2017b), and this strain was not able to bind hydrophobic material, we conclude that the expression of SlpB at the cell surface of JS14 is the key factor mediating the adherent growth (biofilm formation) and binding of this strain to hydrophobic material. Of note, a moonlighting enzyme, dihydrolipoamide acetyltransferase was recently shown to be associated with the S-layer proteins in a commensal P. freudenreichii strain (UF1), from where it conferred increased protection against pathogen infection (Colliou et al, 2017). In the present study, a moonlighting PepN was another protein released together with SlpB from JS14; whether this aminopeptidase was associated with SlpB or whether this protein confers adaptation, for example to environments containing milk casein, or adherence to hydrophilic/-phobic surfaces remains to be shown.…”
Section: Discussionmentioning
confidence: 99%