Commensal microbes provide first line defense against                        <i>Listeria monocytogenes</i> infection

Becattini, Simone; Littmann, Eric R.; Carter, Rebecca A.; Kim, Sohn G.; Morjaria, Sejal; Ling, Lilan; Gyaltshen, Yangtsho; Fontana, Emily; Taur, Ying; Leiner, Ingrid; Pamer, Eric G.

doi:10.1084/jem.20170495

Cited by 188 publications

(178 citation statements)

References 81 publications

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“…While it has been argued that the recovery of a complex microbiota is important for reestablishing colonization resistance, 66 a growing number of studies that analyzed the microbiome of antibiotic-treated mice has led to a compelling argument for, and the subsequent identification of, a few key members that are sufficient to protect against specific pathogens, including C. difficile , VRE, and Listeria monocytogenes . 67–69 These studies demonstrated that in mouse cohorts treated with antibiotics, there is a wide distribution in the degree of susceptibility to intestinal pathogen colonization following partial microbiota recovery. Comparing mice that are highly susceptible to pathogen colonization with resistant mice revealed that both groups can have a microbiota with equally low diversity, but that the specific bacterial taxa compositions varied.…”

Section: | Colonization Resistancementioning

confidence: 99%

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The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens

Kim

Covington

Pamer

2017

Immunological Reviews

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552

446

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Summary The human gastrointestinal tract hosts a diverse network of microorganisms, collectively known as the microbiota that plays an important role in health and disease. For instance, the intestinal microbiota can prevent invading microbes from colonizing the gastrointestinal tract, a phenomenon known as colonization resistance. Perturbations to the microbiota, such as antibiotic administration, can alter microbial composition and result in the loss of colonization resistance. Consequently, the host may be rendered susceptible to colonization by a pathogen. This is a particularly relevant concern in the hospital setting, where antibiotic use and antibiotic-resistant pathogen exposure are more frequent. Many nosocomial infections arise from gastrointestinal colonization. Due to their resistance to antibiotics, treatment is often very challenging. However, recent studies have demonstrated that manipulating the commensal microbiota can prevent and treat various infections in the intestine. In this review, we discuss the members of the microbiota, as well as the mechanisms, that govern colonization resistance against specific pathogens. We also review the effects of antibiotics on the microbiota, as well as the unique epidemiology of immunocompromised patients that renders them a particularly high-risk population to intestinal nosocomial infections.

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Section: | Colonization Resistancementioning

confidence: 99%

“…This strategy led to the recent identification of a four-member bacterial consortia that, upon colonizing germ-free mice, confer in vivo resistance to Listeria monocytogenes infection. 69 …”

Section: | Colonization Resistancementioning

confidence: 99%

The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens

Kim

Covington

Pamer

2017

Immunological Reviews

Self Cite

552

446

View full text Add to dashboard Cite

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“…Gut microbes play important roles in resisting colonization and protecting the host from infection by pathogenic microbes . For example, commensal bacteria prevent infection by enteropathogenic bacteria such as Listeria monocytogenes , Citrobacter rodentium , Salmonella typhimurium , vancomycin‐resistant Enterococcus and Clostridium difficile . On the basis of the commensal bacterial characteristics that protect the host from pathogen colonization, FMT, a therapeutic strategy using commensal bacteria, has been developed and implemented and found to eradicate C. Difficile infection in humans…”

Section: Introductionmentioning

confidence: 99%

Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract

Matsuo

Haku

et al. 2019

Microbiology and Immunology

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Gut microbes symbiotically colonize the gastrointestinal (GI) tract, interacting with each other and their host to maintain GI tract homeostasis. Recent reports have shown that gut microbes help protect the gut from colonization by pathogenic microbes. Here, we report that commensal microbes prevent colonization of the GI tract by the pathogenic fungus, Candida albicans. Wild‐type specific pathogen‐free (SPF) mice are resistant to C. albicans colonization of the GI tract. However, administering certain antibiotics to SPF mice enables C. albicans colonization. Quantitative kinetics of commensal bacteria are inversely correlated with the number of C. albicans in the gut. Here, we provide further evidence that transplantation of fecal microbiota is effective in preventing Candida colonization of the GI tract. These data demonstrate the importance of commensal bacteria as a barrier for the GI tract surface and highlight the potential clinical applications of commensal bacteria in preventing pathogenic fungal infections.

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“…There are probably strain-specific impediments preventing successful transmission of resistance plasmids (Anisimova & Yarullina, 2018). Interestingly, most of these genera produce bacteriocins that inhibit the growth of L. monocytogenes (Arihara, Cassens, & Luchansky, 1993;Becattini et al, 2017;Becattini & Pamer, 2018;Fisher & Phillips, 2009), possibly impairing cell-to-cell contact. L. monocytogenes lineage II, which is more resistant to bacteriocins, harbors plasmids more often than lineage I (Orsi, Bakker, & Wiedmann, 2011).…”

Section: Mobile Genetic Elementsmentioning

confidence: 99%

Ecogenetics of antibiotic resistance in Listeria monocytogenes

Baquero

Lanza

Duval

et al. 2020

Molecular Microbiology

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The acquisition process of antibiotic resistance in an otherwise susceptible organism is shaped by the ecology of the species. Unlike other relevant human pathogens, Listeria monocytogenes has maintained a high rate of susceptibility to the antibiotics used for decades to treat human and animal infections. However, L. monocytogenes can acquire antibiotic resistance genes from other organisms’ plasmids and conjugative transposons. Ecological factors could account for its susceptibility. L. monocytogenes is ubiquitous in nature, most frequently including reservoirs unexposed to antibiotics, including intracellular sanctuaries. L. monocytogenes has a remarkably closed genome, reflecting limited community interactions, small population sizes and high niche specialization. The L. monocytogenes species is divided into variants that are specialized in small specific niches, which reduces the possibility of coexistence with potential donors of antibiotic resistance. Interactions with potential donors are also hampered by interspecies antagonism. However, occasional increases in population sizes (and thus the possibility of acquiring antibiotic resistance) can derive from selection of the species based on intrinsic or acquired resistance to antibiotics, biocides, heavy metals or by a natural tolerance to extreme conditions. High‐quality surveillance of the emergence of resistance to the key drugs used in primary therapy is mandatory.

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Commensal microbes provide first line defense against Listeria monocytogenes infection

Cited by 188 publications

References 81 publications

The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens

The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens

Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract

Ecogenetics of antibiotic resistance in Listeria monocytogenes

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