Commensal bacteria protect against food allergen sensitization

Stefka, Andrew; Feehley, Taylor; Tripathi, Prabhanshu; Qiu, Ju; McCoy, Kathleen; Mazmanian, Sarkis K.; Tjota, Melissa Y.; Seo, Goo-Young; Cao, Severine; Theriault, Betty; Antonopoulos, Dionysios A.; Zhou, Liang; Chang, Eugene B.; Fu, Yang–Xin; Nagler, Cathryn R.

doi:10.1073/pnas.1412008111

Cited by 667 publications

(688 citation statements)

References 39 publications

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“…Consistent with these functions, SCFAs were implicated in anti-inflammatory properties of a mix of 17 human-derived Clostridia strains (Atarashi et al, 2013;Smith et al, 2013). Gut microbial communities harboring Clostridia are additionally beneficial in that they regulate immune function and epithelial permeability to food antigens to protect against allergen sensitization (Stefka et al, 2014).…”

Section: Introductionmentioning

confidence: 82%

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Schirmer¹,

Smeekens²,

Vlamakis³

et al. 2016

Cell

226

196

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SummaryGut microbial dysbioses are linked to aberrant immune responses, which are often accompanied by abnormal production of inflammatory cytokines. As part of the Human Functional Genomics * Correspondence: xavier@molbio.mgh.harvard.edu (R.J.X.), mihai.netea@radboudumc.nl (M.G.N.). Lead ContactPublisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Author ContributionsMS performed the metagenomics data analyses and correlation analyses. SPS, MJ, MO, AK, and MJB performed the immunological assays and processed and analyzed the data. MS, HV, EAF, CH, MGN, and RJX interpreted the results. MS, EAF, and CH led the computational methods and research development. SPS, MJ, and MO collected clinical samples. SPS, TJ, and LJ performed functional validation experiments. MS, SPS, HV, CH, MGN, and RJX assembled and wrote the paper. MS, HV, MGN, and RJX served as project leaders. JF, AZ, LABJ, CW, MGN, and RJX designed the cohort study. CH, CW, MGN, and RJX served as principal investigators. Table S1. Related to Figure 3. Correlation coefficients for all significant species associations Table S2. Related to Figure 3. FDR values for all significant species associations Table S3. Related to Figure 3. Correlation coefficients for all significant genus associations Table S4. Related to Figure 3. FDR values for all significant genus associations Table S5. Related to Figure 4. Correlation coefficients for all significant pathway associations Table S6. Related to Figure 4. FDR values for all significant pathway associations Table S7. Related to Figure 4. Correlation coefficients for all significant GO category associations Table S8. Related to Figure 4. FDR values for all significant GO category associations HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptProject (HFGP), we investigate how differences in composition and function of gut microbial communities may contribute to inter-individual variation in cytokine responses to microbial stimulations in healthy humans. We observe microbiome-cytokine interaction patterns that are stimulus-specific, cytokine-specific, and cytokine-and stimulus-specific. Validation of two predicted host-microbial interactions reveal that TNFα and IFNγ production are associated with specific microbial metabolic pathways: palmitoleic acid metabolism and tryptophan degradation to tryptophol. Besides providing a resource of predicted microbially-derived mediators that influence immune phenotypes in response to common microorganisms, these data can help to define principles for understanding disease susceptibility. The three HFGP stud...

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Section: Introductionmentioning

confidence: 82%

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Schirmer¹,

Smeekens²,

Vlamakis³

et al. 2016

Cell

226

196

View full text Add to dashboard Cite

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“…In the mouth, alteration of the local microbiota will produce dental caries and periodontitis; in the stomach, reflux, gastritis, stomach ulcers, dyspepsia; in the intestine, conditions such as irritable bowel syndrome, chronic diarrhoea or constipation, malabsorption, diverticulitis, etc. [12][13][14].…”

Section: The Human Microbiomementioning

confidence: 99%

Equibiotics: a new type of phyto-drug equilibrating local microbiota

Lozoya¹,

Gascn-Muro²,

Agero³

et al. 2018

Fighting Antimicrobial Resistance

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“…e highest microbial exposure to the host takes place at the gut epithelium and thus, its e ects on type 2 immune responses can be expected to be strongest at this site. In a murine model of orally inAllergo J Int 2016; 25: 114-23 duced food allergy antibiotic-treated as well as germfree mice showed more e cient sensitization to peanut extract that resulted in more severe anaphylactic reactions upon systemic allergen challenge [37]. Besides its role for the development of the immune system, the microbiota also a ects the mucus layer and regulates the permeability of the epithelial barrier.…”

Section: Microbiota and Type 2 Immune Responsesmentioning

confidence: 99%

“…Besides its role for the development of the immune system, the microbiota also a ects the mucus layer and regulates the permeability of the epithelial barrier. Indeed, more peanut allergens were found in the serum of sensitized germfree mice compared to conventionally housed mice [37]. Besides allergic in ammation, ulcerative colitis is another non-infectious disease which is (at least in part) based on a type 2 immunopathology [38].…”

Section: Microbiota and Type 2 Immune Responsesmentioning

confidence: 99%

Microbiota, regulatory T cell subsets, and allergic disorders

Ohnmacht¹

2016

Allergo J

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Epidemiologic studies revealed a crucial role of the environment for the increased prevalence of allergic disorders. e microbiota as part of our immediate environment promotes immune diversity that facilitates a well-equilibrated balance between immunity and tolerance. Alterations of our symbiotic microbiota especially in early life is thought to play a fundamental role in de ning susceptibility to the development of allergic diseases during adult life on the population level. Due to a high density of bacteria, viruses and fungi and a large contact surface area for host-microbiota interactions, the most relevant interaction between microbes and our immune system are thought to occur in the gut. e immune system co-evolved with the symbiotic microbiota and adopted a variety of mechanisms to allow a dynamic state of tolerance, including the induction of regulatory T cells (Tregs). Foxp3-expressing Tregs are welldescribed immune regulators in autoimmune and allergic disorders. However, recent years have shown that Tregs can come in di erent avours with di erent regulatory potential and outcome for our immune system. is review summarizes novel ndings from basic immunology research that may help to better understand the interaction between the microbiota, di erentiation of Tregs and its consequences for the onset and regulation of allergic disorders.Cite this as Ohnmacht C. Microbiota, regulatory T cell subsets, and allergic disorders. Allergo J Int 2016;25:114-23

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Commensal bacteria protect against food allergen sensitization

Cited by 667 publications

References 39 publications

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Equibiotics: a new type of phyto-drug equilibrating local microbiota

Microbiota, regulatory T cell subsets, and allergic disorders

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