2021
DOI: 10.1371/journal.ppat.1009880
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Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species

Abstract: Staphylococcus aureus is a human commensal organism and opportunist pathogen, causing potentially fatal disease. The presence of non-pathogenic microflora or their components, at the point of infection, dramatically increases S. aureus pathogenicity, a process termed augmentation. Augmentation is associated with macrophage interaction but by a hitherto unknown mechanism. Here, we demonstrate a breadth of cross-kingdom microorganisms can augment S. aureus disease and that pathogenesis of Enterococcus faecalis c… Show more

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Cited by 11 publications
(16 citation statements)
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“…We have previously established a macrophage infection assay, using both cultured RAW264.7 cells and human monocyte derived macrophages (MDMs), which leads to the formation of bacterial masses 17 , as depicted in Fig. 1 a.…”
Section: Resultsmentioning
confidence: 99%
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“…We have previously established a macrophage infection assay, using both cultured RAW264.7 cells and human monocyte derived macrophages (MDMs), which leads to the formation of bacterial masses 17 , as depicted in Fig. 1 a.…”
Section: Resultsmentioning
confidence: 99%
“…A key facet of the macrophage arsenal employed to combat S. aureus are reactive oxygen species (ROS). ROS are pivotal in a phenomenon termed “augmentation” where the presence of commensal organisms, or their components, within the S. aureus inoculum ameliorates ROS within macrophages leading to increased bacterial survival 17 . This is important as S. aureus will generally infect the host by emerging from the current microflora of the host environment.…”
Section: Introductionmentioning
confidence: 99%
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“…The commensal bacteria found in the anterior naris are S. epidermidis , Cutibacterium acnes , Dolosigranulum pigrum , Finegoldia magna , Corynebacterium spp., Moraxella spp., Peptoniphilus spp., and Anaerococcus spp ( Kumpitsch et al., 2019 ).. S. epidermidis that was used in the current study is one of the most predominant opportunistic bacterial species in the naris, suggesting the great possibility of coexistence of both bacteria species in the same location. Importantly, it has been shown that a broad range of microorganisms including Micrococcus luteus , Escherichia Coli , Roseomonas mucosa , and Saccharomyces cerevisiae are able to augment the S. aureus pathogenicity in sepsis ( Boldock et al., 2018 ; Gibson et al., 2021 ). Indeed, a study of the overall microbial composition in anterior nare bacterial community in 40 healthy individuals revealed that in most of the cases the other commensal strains were much more prevalent in high abundance than S. aureus ( Wos-Oxley et al., 2010 ).…”
Section: Discussionmentioning
confidence: 99%
“…Co-infection of S. aureus and commensal bacteria only led to the proliferation of S. aureus within KCs [ 80 ]. The commensal bacteria augment S. aureus infection by acting as a sink for ROS production, thereby increasing the chance that S. aureus can initiate replication inside KCs [ 81 ]. Many other bacterial, fungal, or parasitic species have been shown to use circulating phagocytes as an opportunity for dissemination, such as Mycobacterium tuberculosis , Listeria monocytogenes , Leishmania , and Cryptococcus neoformans [ 82 , 83 , 84 , 85 ].…”
Section: Bacterial Specificity Of the Intracellular Reservoirmentioning
confidence: 99%