Command Suicidal Hallucination as Initial Presentation of Coronavirus Disease 2019 (COVID-19): A Case Report

Mirza, Junaid; Ganguly, Amvrine; Ostrovskaya, A. A.; Tusher, Alan; Viswanathan, R.

doi:10.1016/j.psym.2020.05.022

Cited by 28 publications

(20 citation statements)

References 12 publications

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“…However, a comparison with preceding years showed that this difference in 2020 was mainly caused by high suicide rates in the period without restrictions. the underlying factors being fear of infection [25][26][27] or severe mental disorders such as hallucinations or delusions [28][29][30] . However, trends in suicide risks cannot be concluded from case reports or case series.…”

Section: Discussionmentioning

confidence: 99%

Trends in suicide rates during the COVID-19 pandemic restrictions in a major German city

Radeloff

Papsdorf

Uhlig³

et al. 2020

Preprint

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Background It remains unclear whether the COVID-19 pandemic is having an impact on suicide rates. Social distancing, economic insecurity and increasing prevalence rates of mental disorders may cause an increase in risk factors for suicide. Methods Data on suicide events in a major city in Germany, and the corresponding life years were provided by the local authorities. For the year 2020, periods without restrictions on freedom of movement and social contact were compared with periods of moderate and severe COVID-19 restrictions. To avoid distortions due to seasonal fluctuations in suicide risk, data from 2020 were compared to data from 2010 to 2019. Outcomes A total of 333 suicides were registered and 2,791,131 life years (LY) were spent between 2010 and 2020. Of these, 42 suicides and 300,834 LY accounted for the year 2020. In 2020, suicide rates (SR, suicides per 100,000 LY) were lower in periods with moderate (SR = 8.5, X^2 = 4.374, p = 0.037) or severe COVID-19 restrictions (SR = 7.0, X^2 = 3.999, p = 0.046) compared with periods without restrictions (SR = 18.0). A comparison with preceding years showed that differences cannot be attributed to seasonal variations. No age- or gender differences were found. Interpretation SR decreased during the COVID-19 restrictions; we expect SR to rise in the medium term. Careful monitoring of SR in the further course of the COVID-19 crisis is therefore urgently needed. The findings have regional reference and should not be over-generalized. Funding This study was conducted without external funding.

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Section: Discussionmentioning

confidence: 99%

Trends in suicide rates during the COVID-19 pandemic restrictions in a major German city

Radeloff

Papsdorf

Uhlig³

et al. 2020

Preprint

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“… 8 Infection from coronaviruses like COVID-19 can cause acute neurological symptoms, 9 and there have been emerging case reports of suicide or suicide attempt that were attributed to COVID-19 infection and COVID-19-related social impacts. 10 11 There is a precedent of elevated suicide-related outcomes following other disaster and crisis events that have economic and social similarities to the COVID-19 pandemic. Increased suicide mortality at the population level was attributed to the USA foreclosure crisis and Great Recession in 2008–2009.…”

Section: Introductionmentioning

confidence: 99%

Suicide attempt and intentional self-harm during the earlier phase of the COVID-19 pandemic in Washtenaw County, Michigan

Bergmans

Larson

2021

J Epidemiol Community Health

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ObjectiveDetermine the early impact of the COVID-19 pandemic on emergency department (ED) encounters for suicide attempt and intentional self-harm at a regional tertiary academic medical centre in Washtenaw County, Michigan, which is one of the wealthier and more diverse counties in the state.MethodsInterrupted time series analysis of daily ED encounters from October 2015 through October 2020 for suicide attempt and intentional self-harm (subject n=3002; 62% female; 78% Caucasian) using an autoregressive integrated moving average modelling approach.ResultsThere were 39.9% (95% CI 22.9% to 53.1%) fewer ED encounters for suicide attempt and intentional self-harm during the first 12 weeks of the COVID-19 pandemic (ie, on or after 10 March 2020, when the first cases of COVID-19 were identified in Michigan).ConclusionsFewer individuals sought emergency care for suicide-related behaviour during the earlier phase of the COVID-19 pandemic than expected when compared to prior years. This suggests initial outbreaks of COVID-19 and state of emergency executive orders did not increase suicide-related behaviour in the short term. More work is needed to determine long-term impacts of the COVID-19 pandemic on suicide-related behaviour and whether there are high-risk groups.

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“…From the day of first reporting, above 4.5 million cases were confirmed globally with more than 2.47 lacs deaths [ 4 , 5 ]. Although immune-compromised patient, older people and people with disease history may develop dangerous outcome like acute respiratory distress syndrome (ARDS) [ 2 ], many research suggested that cancer patients are more susceptible to SARS-CoV-2 infection than individuals with COVID-19 alone because of their systemic immunosuppressive state caused by the malignancy [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Metastasis in the lung makes patients seriously vulnerable to COVID-19 that might result in poor prognosis, pneumonia, and various lung problem [ 8 ]. Several signs and symptoms were found in COVID-19 patients, including invasive lung lesions, fatigue, fever, breathlessness, cough, and many others [ 5 , 9 , 10 ]. Due to elevated cytokine levels such as TNFα, MIP1A, GCSF, IL (2, 7, 10), which may develop into worse outcomes like pneumonia, respiratory failure, and death have been described [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of angiotensin-converting enzyme 2 (ACE2) protein as the potential biomarker in SARS-CoV-2 infection-related lung cancer using computational analyses

Samad¹,

Jafar

Rafi

2020

Genomics

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COVID-19 is a pandemic that began to spread worldwide caused by SARS-CoV-2. Lung cancer patients are more susceptible to SARS-CoV-2 infection. The SARS-CoV-2 enters into the host by the ACE2 receptor. Thus, ACE2 is the key to understand the mechanism of SARS-CoV-2 infection. However, the lack of knowledge about the biomarker of COVID-19 warrants the development of ACE2 biomarkers. The analysis of ACE2 expression in lung cancer was performed using The Cancer Genome Atlas (TCGA). Therefore, we investigated the prognosis, clinical characteristics, and mutational analysis of lung cancer. We also analyzed the shared proteins between the COVID-19 and lung cancer, protein-protein interactions, gene-miRNAs, gene-transcription factors (TFs), and the signaling pathway. Finally, we compared the mRNA expression of ACE2 and its co-expressed proteins using the TCGA. The up-regulation of ACE2 in lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC) was found irrespective of gender and age. We found the low survival rate in high expression of ACE2 in lung cancer patients and 16 mutational positions. The functional assessment of targeted 12,671, 3107, and 29 positive genes were found in COVID-19 disease, LUAD, and LUSC, respectively. Then, we identified eight common genes that interact with 20 genes, 219 miRNAs, and 16 TFs. The common genes performed the mRNA expression in lung cancer, which proved the ACE2 is the best potential biomarker compared to co-expressed genes. This study uncovers the relationship between COVID-19 disease and lung cancer. We identified ACE2 and also its co-expressed proteins are the potential biomarker and therapy as the current COVID-19 disease and lung cancer.

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Command Suicidal Hallucination as Initial Presentation of Coronavirus Disease 2019 (COVID-19): A Case Report

Cited by 28 publications

References 12 publications

Trends in suicide rates during the COVID-19 pandemic restrictions in a major German city

Trends in suicide rates during the COVID-19 pandemic restrictions in a major German city

Suicide attempt and intentional self-harm during the earlier phase of the COVID-19 pandemic in Washtenaw County, Michigan

Identification of angiotensin-converting enzyme 2 (ACE2) protein as the potential biomarker in SARS-CoV-2 infection-related lung cancer using computational analyses

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