The aim of this work is the analysis of the characteristics of biodiesel combustion in industrial burners in order to optimize the overall combustion process. A CFD model has been employed to simulate the fuel atomization process and the liquid spray evaporation that occur in a burner. A pressure swirl atomizer has been considered and a "flamelet" model has been implemented to simulate the fuel combustion. The validation of the numerical model has been carried out by a comparison with the experimental data provided by NIST (National Institute for Standards and Technology) for methanol injection and combustion in a cylindrical vessel with an injector axially located. The model has been employed to analyze the behavior of biodiesel fuel, inside the NIST burner, and to make a comparison with the injection and combustion of methanol. Biodiesel has been modelled as methyl-decanoate. A parametric study, by varying the injector included half-angle and the inlet air mass flow rate, has been carried out in order to identify an optimal configuration in terms of flame temperature and pollutant distributions as a result of the combustion process.