Combustion-derived nanoparticle exposure and household solid fuel use in Xuanwei and Fuyuan, China

Hosgood, H. Dean; Lan, Qing; Vermeulen, Roel; Hu, Wei; Reiss, Boris; Coble, Joseph; Wei, Fusheng; Xu, Jianing; Wu, Guoping; Rothman, Nat

doi:10.1080/09603123.2012.684147

Cited by 19 publications

(13 citation statements)

References 34 publications

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“…5, 6 Constituents of smoky coal and its emissions have been explored in an attempt to pinpoint those that account for lung cancer risk. 7–10, 25, 26 Here, we integrated untargeted adductomics with external exposure measurements to investigate the influence of fuel type and external exposures on downstream biological processes that are reflected by Cys34 adducts.…”

Section: Discussionmentioning

confidence: 99%

Profiling the Serum Albumin Cys34 Adductome of Solid Fuel Users in Xuanwei and Fuyuan, China

Grigoryan

Edmands

et al. 2016

Environ. Sci. Technol.

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Xuanwei and Fuyuan counties in China have the highest lung cancer rates in the world due to household air pollution from combustion of smoky coal for cooking and heating. To discover potential biomarkers of indoor combustion products, we profiled adducts at the Cys34 locus of human serum albumin (HSA) in 29 nonsmoking Xuanwei and Fuyuan females who used smoky coal, smokeless coal or wood, and 10 local controls who used electricity or gas fuel. Our untargeted ‘adductomics’ method detected 50 tryptic peptides of HSA, containing Cys34 and prominent post-translational modifications. Putative adducts included Cys34 oxidation products, mixed disulfides, rearrangements and truncations. The most significant differences in adduct levels across fuel types were observed for S-glutathione (S-GSH) and S-γ-glutamylcysteine (S-γ-GluCys), both of which were present at lower levels in subjects exposed to combustion products than in controls. After adjustment for age and personal measurements of airborne benzo(a)pyrene, the largest reductions in levels of S-GSH and S-γ-GluCys relative to controls were observed for users of smoky coal, compared to users of smokeless coal and wood. These results point to possible depletion of GSH, an essential antioxidant, and its precursor γ-GluCys in nonsmoking females exposed to indoor-combustion products in Xuanwei and Fuyuan, China.

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Section: Discussionmentioning

confidence: 99%

Profiling the Serum Albumin Cys34 Adductome of Solid Fuel Users in Xuanwei and Fuyuan, China

Grigoryan

Edmands

et al. 2016

Environ. Sci. Technol.

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“…The reduction in PM abs measurements among households using portable stoves is likely a reflection of how these stoves are operated. Portable stoves are designed to be lit outdoors and only brought indoors after the initial ignition period, which is the period during which particulate emissions are maximal (Hosgood et al, 2012). As the stove is moved away from the indoor measurement devices, and residents leave the stoves unattended while outdoors, it therefore follows that indoor and personal measurements will be lower.…”

Section: Discussionmentioning

confidence: 99%

Outdoor, indoor, and personal black carbon exposure from cookstoves burning solid fuels

Downward

Rothman

et al. 2015

Indoor Air

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Background Black carbon (BC) emissions from solid fuel combustion are associated with increased morbidity and mortality and are important drivers of climate change. We studied BC measurements, approximated by particulate matter (PM2.5) absorbance, in rural Yunnan province, China whose residents use a variety of solid fuels for cooking and heating including: bituminous and anthracite coal, and wood. Methods Measurements were taken over 2 consecutive 24 h periods from 163 households in 30 villages. PM2.5 absorbance (PMabs) was measured using an EEL 043 Smoke Stain Reflectometer. Results PMabs measurements were higher in wood burning households (16.3 × 10−5 m−1) than bituminous and anthracite coal households (12 and 5.1 × 10−5 m−1 respectively). Among bituminous coal users, measurements varied by a factor of two depending on the coal source. Portable stoves (which are lit outdoors and brought indoors for use) were associated with reduced PMabs levels, but no other impact of stove design was observed. Outdoor measurements were positively correlated with and approximately half the level of indoor measurements (r= 0.49, p<0.01). Conclusion Measurements of BC (as approximated by PMabs) in this population are modulated by fuel type and source. This provides valuable insight into potential morbidity, mortality and climate change contributions of domestic usage of solid fuels.

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“…Xuanwei, located in southwestern province of Yunnan, China, is a coal-rich county and residents have traditionally burned "smoky coal" in unvented fire pits or stoves for home cooking and heating until the 1970s. Xuanwei smoky coal has relatively high aromatic and low sulfur content, and, as its name implies, smokes heavily on combustion [9]. Burning smoky coal in poor indoor ventilation condition generated high levels of particulate matter (up to 24.4 mg/m 3 ), extractable organic matter (up to 17.6 mg/m 3 ), and carcinogenic policyclic aromatic hydrocarbons (PAHs, up to 58.33 mg/ m 3 ) [10,11], leading to a 7.7-fold increased risk of the area's lung cancer and the risks were similar between women and men [12].…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Analysis of mRNA Expression Profiling Identified Lung Cancer-Related Gene in Xuanwei, China

Wu¹,

Song²,

Xiong³

et al. 2018

Clin. Lab.

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Background: The morbidity and mortality of lung cancer in Xuanwei (LCXW) is among the highest in China for both males and females and increases constantly. The underlying molecular changes associated with LCXW are still unclear. The purpose of this study was to screen out potential cancer-related genes which may become promising biomarkers of LCXW. Methods: Differentially expressed genes (DEGs) were detected by the expression microarrays in 29 paired LCXW tissues (tumor tissue and matched adjacent non-cancerous lung tissues). Integrated with bioinformatic analyses, a literature review was applied for screening out important cancer-related genes. An additional 44 paired LCXW samples were collected to verify the transcription and expression levels of the candidate gene by qRT-PCR and Western blotting. The relationship between the candidate genes and clinical pathological features were evaluated using Fisher's test. Results: mRNA expression microarrays revealed that the LCXW patients harbored 2,424 differentially expressed genes (fold change ≥ 2.0). Of these genes, 1,636 were up-regulated while the other 788 genes were down-regulated. Forty previously reported DNA repair genes associated with PAHs exposure were identified by microarrays. Bioinformatic analyses indicated down-regulated ANXA3 in LCXW patients which was closely related to pathological stage and involved in the regulation of a variety of biological responses. Review of the literature on ANXA3 found its down-regulation was a distinct expression pattern compared with lung cancer occurring in other geographic areas. qRT-PCR and Western blotting confirmed the down-regulation of ANXA3 was associated with LCXW. The correlation analysis of clinical features showed down-regulated ANXA3 was correlated to the progression of pathological stage. Conclusions: The LCXW patients harbored more DEGs, and these DEGs were involved in a wide range of pathways and biological function damage. We preliminarily suggested ANXA3 may be a potential LCXW related gene. ANXA3 may serve as a promising biomarker for diagnosis of LCXW.

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Combustion-derived nanoparticle exposure and household solid fuel use in Xuanwei and Fuyuan, China

Cited by 19 publications

References 34 publications

Profiling the Serum Albumin Cys34 Adductome of Solid Fuel Users in Xuanwei and Fuyuan, China

Profiling the Serum Albumin Cys34 Adductome of Solid Fuel Users in Xuanwei and Fuyuan, China

Outdoor, indoor, and personal black carbon exposure from cookstoves burning solid fuels

Genome-Wide Analysis of mRNA Expression Profiling Identified Lung Cancer-Related Gene in Xuanwei, China

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