Comblike poly(ethylene oxide)/hydrophobic C6 branched chitosan surfactant polymers as anti-infection surface modifying agents

Mai-ngam, Katanchalee

doi:10.1016/j.colsurfb.2006.03.007

Cited by 24 publications

(22 citation statements)

References 30 publications

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“…Mai-Ngam, on the other hand, reported on classic surfactant behavior and high surface activity of low-molecular weight chitosan hydrochloride (Mw 5000 g/mol, FA 0.035) based on surface tension measurements. Further, it was suggested that the low Mw chitosan formed a monolayer at the air-water interface [62]. The results are in agreement with the ones reported on by Calero et al, through combined surface tension and surface viscoelasticity measurements the group found that chitosan formed a viscoelastic film at the oil-water interface and significantly reduced the surface tension [66].…”

Section: Surface Activity Of Chitosansupporting

confidence: 82%

“…The surface (liquid-vapour, i.e., water-air) and/or interfacial (liquid-liquid, i.e., oil-water) tension of chitosan solutions of varying Mw, FA and concentration have been reported in some studies [60][61][62][63][64][65]. Payet et al studied the interfacial properties of chitosan, both at the air-water surface as well as at the oil-water interface.…”

Section: Surface Activity Of Chitosanmentioning

confidence: 99%

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Chitosan: Gels and Interfacial Properties

et al. 2015

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Abstract:Chitosan is a unique biopolymer in the respect that it is abundant, cationic, low-toxic, non-immunogenic and biodegradable. The relative occurrence of the two monomeric building units (N-acetyl-glucosamine and D-glucosamine) is crucial to whether chitosan is predominantly an ampholyte or predominantly a polyelectrolyte at acidic pH-values. The chemical composition is not only crucial to its surface activity properties, but also to whether and why chitosan can undergo a sol-gel transition. This review gives an overview of chitosan hydrogels and their biomedical applications, e.g., in tissue engineering and drug delivery, as well as the chitosan's surface activity and its role in emulsion formation, stabilization and destabilization. Previously unpublished original data where chitosan acts as an emulsifier and flocculant are presented and discussed, showing that highly-acetylated chitosans can act both as an emulsifier and as a flocculant.

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Section: Surface Activity Of Chitosansupporting

confidence: 82%

Section: Surface Activity Of Chitosanmentioning

confidence: 99%

Chitosan: Gels and Interfacial Properties

et al. 2015

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“…Surfactants are amphiphilic molecules, as they contain both hydrophilic and hydrophobic moieties that allow them to be easily immobilized on a surface, and are commonly used to lower the surface tension of a material. Surfactants have been shown to inhibit the adhesion of gram-negative and gram-positive bacteria to solid surfaces (14,18,29,33,37). When the impact of surfactants on microbial life is considered, cationic surfactants (such as quaternary imidazolium compounds) are often the most toxic to microorganisms and are used as antimicrobials.…”

mentioning

confidence: 99%

Polysorbate 80 Inhibition of Pseudomonas aeruginosa Biofilm Formation and Its Cleavage by the Secreted Lipase LipA

Toutain-Kidd¹,

Kadivar

Bramante

et al. 2009

Antimicrob Agents Chemother

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Surface-associated bacterial communities known as biofilms are an important source of nosocomial infections. Microorganisms such as Pseudomonas aeruginosa can colonize the abiotic surfaces of medical implants, leading to chronic infections that are difficult to eradicate. Our study demonstrates that polysorbate 80 (PS80), a surfactant commonly added to food and medicines, is able to inhibit biofilm formation by P. aeruginosa on a variety of surfaces, including contact lenses. Many clinical isolates of P. aeruginosa, as well as gram-negative and gram-positive clinical isolates, were also inhibited in their ability to form biofilms in the presence of PS80. A P. aeruginosa mutant able to form biofilms in the presence of this surfactant was identified and characterized, and it was revealed that this mutant overexpresses a lipase, LipA. Surfactants such as PS80 can be cleaved by lipases, and we demonstrate that PS80 is cleaved by LipA at its ester bond. Finally, polyethoxylated(20) oleyl alcohol, a chemical with a structure that is similar to that of PS80 but that lacks the ester bond of PS80, can inhibit the biofilm formation of P. aeruginosa strains, including the mutant overexpressing LipA. Our results demonstrate that surfactants such as PS80 can inhibit bacterial biofilm formation on medically relevant materials at concentrations demonstrated to be safe in humans and suggest that the understanding of the mechanisms of bacterial resistance to such surfactants will be important in developing clinically effective derivatives.

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“…LWCS can be utilized as one of the basic materials for preparing different polymeric surfactants [30][31][32][33][34][35][36]. The polymeric surfactants based on LWCS display good biodegradable, biocompatible and bioactive properties, and have been widely accepted as a material for tissue engineering and a carrier for various bioactive compounds [14,16,26,37]. Dehydroabietylamine (DHA), a compound derived from dehydroabietic acid, is not only environmentally friendly and has good biological degradability but also favorable reaction performance [38,39].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Performance of a Novel Polymeric Cationic Surfactant Based on Low Molecular Weight Chitosan and 3‐Chloro‐2‐Hydroxypropyl Dimethyl Dehydroabietyl Ammonium Chloride (CHPDMDHA)

Fan

Cai

Zhu

et al. 2015

J Surfact & Detergents

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A series of novel polymeric cationic surfactants based on low molecular weight chitosan (LWCS) and 3-chloro-2-hydroxypropyl dimethyl dehydroabietyl ammonium chloride (CHPDMDHA), LWCS-g-CHPDMDHA, were obtained by the grafting modification of LWCS with CHPDMDHA as grafting agent. The structure of LWCS-g-CHPDMDHA was confirmed by FT-IR and 1 H NMR, and the degree of quaternizing substitution (DS) of LWCS-g-CHPDMDHA was determined according to the results of elemental analysis. The aggregation behavior and surface activities of LWCS-g-CHPDMDHA in aqueous solution were investigated by transmission electron microscopy (TEM) and determination of surface tension, respectively. The experimental results showed that the DS and molecular weight (M w ) of LWCS have significant influence on the critical micelle concentrations (CMC) and the surface tensions at the CMC (c cmc ). The shape of aggregates changed with the variation of concentration of LWCS-g-CHPDMDHA in aqueous solution. When the LWCS-g-CHPDMDHA was utilized as an emulsifier, the increase of DS of LWCS-g-CHPDMDHA and M w of LWCS were favorable for improving the stability of emulsions composed of water and benzene.

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Comblike poly(ethylene oxide)/hydrophobic C6 branched chitosan surfactant polymers as anti-infection surface modifying agents

Cited by 24 publications

References 30 publications

Chitosan: Gels and Interfacial Properties

Chitosan: Gels and Interfacial Properties

Polysorbate 80 Inhibition of Pseudomonas aeruginosa Biofilm Formation and Its Cleavage by the Secreted Lipase LipA

Synthesis, Characterization, and Performance of a Novel Polymeric Cationic Surfactant Based on Low Molecular Weight Chitosan and 3‐Chloro‐2‐Hydroxypropyl Dimethyl Dehydroabietyl Ammonium Chloride (CHPDMDHA)

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