Combining Ultrafiltration and Nanofiltration to Obtain a Concentrated Extract of Purified Polyphenols from Wet Olive Pomace

Sánchez-Arévalo, Carmen M.; García-Serrano, Ane Pérez; Vincent‐Vela, María‐Cinta; Álvarez-Blanco, Silvia

doi:10.3390/membranes13020119

Cited by 6 publications

(3 citation statements)

References 58 publications

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“…In a previous work by the authors, the rejection of phenolic compounds during the ultrafiltration of aqueous extracts (without ethanol) of wet olive pomace was reported, employing the same membrane (UP005) in cross-flow mode [41]. If those results are compared with this work, it is noticeable that lower rejections of biophenols are obtained when the extract is solvent-based.…”

Section: Discussionmentioning

confidence: 63%

Integrated Membrane Process in Organic Media: Combining Organic Solvent Ultrafiltration, Nanofiltration, and Reverse Osmosis to Purify and Concentrate the Phenolic Compounds from Wet Olive Pomace

Sánchez-Arévalo,

Aldegheri,

Vincent-Vela

et al. 2024

IJMS

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Phenolic compounds from a hydroalcoholic extract of wet olive pomace were purified and concentrated by an integrated membrane process in organic media. First, UF010104 (Solsep BV) and UP005 (Microdyn Nadir) membranes were tested to be implemented in the ultrafiltration stage, with the aim of purifying the extract and obtaining a permeate enriched in phenolic compounds. Despite the high flux observed with the UF010104 membrane (20.4 ± 0.7 L·h−1·m−2, at 2 bar), the UP005 membrane was selected because of a more suitable selectivity. Even though some secoiridoids were rejected, the permeate stream obtained with this membrane contained high concentrations of valuable simple phenols and phenolic acids, whereas sugars and macromolecules were retained. Then, the ultrafiltration permeate was subjected to a nanofiltration step employing an NF270 membrane (DuPont) for a further purification and fractionation of the phenolic compounds. The permeate flux was 50.2 ± 0.2 L·h−1·m−2, working at 15 bar. Hydroxytyrosol and some phenolic acids (such as vanillic acid, caffeic acid, and ferulic acid) were recovered in the permeate, which was later concentrated by reverse osmosis employing an NF90 membrane. The permeate flux obtained with this membrane was 15.3 ± 0.3 L·h−1·m−2. The concentrated phenolic mixture that was obtained may have important applications as a powerful antioxidant and for the prevention of diabetes and neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 63%

Integrated Membrane Process in Organic Media: Combining Organic Solvent Ultrafiltration, Nanofiltration, and Reverse Osmosis to Purify and Concentrate the Phenolic Compounds from Wet Olive Pomace

Sánchez-Arévalo,

Aldegheri,

Vincent-Vela

et al. 2024

IJMS

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“…These molecules can sequester or inhibit reactive oxygen and nitrogen species, reducing potential inflammatory events. At the same time, thanks to their anti-radical power, they can transfer electrons to free radicals, preventing adverse effects on the organism [7]. Different studies have highlighted the diverse biological properties of polyphenols, including anti-inflammatory, antioxidant, cardioprotective, and neuroprotective activities [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Temperature-Dependent Olive Pomace Extraction for Obtaining Bioactive Compounds Preventing the Death of Murine Cortical Neurons

Casazza,

Capraro,

Pedrazzi

et al. 2024

IJMS

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High-pressure and temperature extraction (HPTE) can effectively recover bioactive compounds from olive pomace (OP). HPTE extract obtained by extracting OP with ethanol and water (50:50 v/v) at 180 °C for 90 min demonstrated a pronounced ability to preserve intracellular calcium homeostasis, shielding neurons from the harmful effects induced by N-methyl-d-aspartate (NMDA) receptor (NMDAR) overactivation, such as aberrant calpain activation. In this study, the extraction temperature was changed from 37 to 180 °C, and the extracts were evaluated for their antioxidant potency and ability to preserve crucial intracellular Ca2+-homeostasis necessary for neuronal survival. Additionally, to verify the temperature-induced activity of the extract, further extractions on the exhausted olive pomace were conducted, aiming to identify variations in the quality and quantity of extracted phenolic molecules through HPLC analysis. The results revealed a significant increase in bioactive compounds as a function of temperature variation, reaching 6.31 ± 0.09 mgCAE/mL extract for the extraction performed at 180 °C. Subsequent extraction of the exhausted residues yielded extracts that remained active in preventing calcium-induced cell death. Moreover, despite increased antiradical power, extracts re-treated at 180 °C did not display cell protection activity. Our results indicate that the molecules able to maintain physiological Ca2+-homeostasis in murine cortical neurons in conditions of cytotoxic stimulation of NMDAR are wholly recovered from olive pomace only following extraction performed at 180 °C.

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“…Therefore, it is necessary to develop treatment techniques that manage to provide treatment in an energy-efficient manner. The recovery of compounds present in wastewater begins as a strategy to amortize wastewater treatment, since it is possible to obtain products with high profit from waste, promoting a circular economy [ 3 ]. In OMW, the phenolic compounds mainly provide its phytotoxic character.…”

Section: Introductionmentioning

confidence: 99%

Theoretical Model for the Prediction of Water Flux during the Concentration of an Olive Mill Wastewater Model Solution by Means of Forward Osmosis

Cifuentes-Cabezas,

Álvarez-Blanco,

Mendoza-Roca

et al. 2023

Membranes

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Currently, understanding the dynamics of the interaction between the agents in a process is one of the most important factors regarding its operation and design. Membrane processes for industrial wastewater management are not strangers to this topic. One such example is the concentration of compounds with high added value, such as the phenolic compounds present in olive mill wastewater (OMW). This process is a viable option, thanks to the forward osmosis (FO) process, osmotically driven by a saline stream. In this context, the transport of the solute and the solvent through the FO membranes, although essential to the process, remains problematic. This paper presents a study to predict, by means of a theoretical model, the water flux for two membranes (a cellulose triacetate flat sheet and a polyamide hollow fiber with integrated aquaporin proteins) with different characteristics using a sodium chloride solution as the draw solution (DS). The novelty of this model is the consideration of the contribution of organic compounds (in addition to the inorganic salts) to the osmotic pressure in the feed side. Moreover, the geometry of the modules and the characteristics of the membranes were also considered. The model was developed with the ability to run under different conditions, with or without tyrosol (the compound chosen as representative of OMW phenolic compounds) in the feed solution (FS), and was fitted and evaluated using experimental data. The results presented a variability in the model prediction, which was a function of both the membrane used and the FS and DS, with a greater influence of tyrosol observed on the permeate flux in the flat cellulose triacetate membrane.

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Combining Ultrafiltration and Nanofiltration to Obtain a Concentrated Extract of Purified Polyphenols from Wet Olive Pomace

Cited by 6 publications

References 58 publications

Integrated Membrane Process in Organic Media: Combining Organic Solvent Ultrafiltration, Nanofiltration, and Reverse Osmosis to Purify and Concentrate the Phenolic Compounds from Wet Olive Pomace

Integrated Membrane Process in Organic Media: Combining Organic Solvent Ultrafiltration, Nanofiltration, and Reverse Osmosis to Purify and Concentrate the Phenolic Compounds from Wet Olive Pomace

Temperature-Dependent Olive Pomace Extraction for Obtaining Bioactive Compounds Preventing the Death of Murine Cortical Neurons

Theoretical Model for the Prediction of Water Flux during the Concentration of an Olive Mill Wastewater Model Solution by Means of Forward Osmosis

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