Combining therapies for the treatment of migraine: is there a role?

Memantine in the Preventive Treatment for Migraine and Refractory Migraine

“…In truth, although still based on anecdotal personal experience, we consider the association between topiramate and memantine an attractive scheme of treatment so far. As physicians always trying to improve clinical outcomes in migraineurs, the combination of synergistic pharmacological agents aiming at different neurotransmitter systems has been our approach for longer than 20 years dedicated to headache patients in tertiary settings 9‐13 . Combining memantine with drugs acting on serotonergic or noradrenergic pathways may also provide better results in the reduction of headache days without increasing tolerability issues.…”

Is the Generally Held View That Intravenous Dihydroergotamine Is Effective in Migraine Based on Wrong “General Consensus” of One Trial? A Critical Review of the Trial and Subsequent Quotations

“…According to a search on Google Scholar on April 26, 2015, the study by Callaham and Raskin has been cited 153 times. However, a control with hand counting resulted in 150 citations, 111 of which were retrieved and included , . Three citations were ordered from the library system, but were not retrieved.…”

The state of the art in treating patients with a dual diagnosis of chronic migraine and medication-overuse headache

“…7,10,14,22 -We frequently suggested that rational combinations should be the best, but always considering costs, independence from professionals, health plans and the overload of bureaucratic requirements. [30][31][32][33][34][35] It has been our approach during decades, initiating with two or three agents, such as a tricyclic antidepressant plus a neuromodulator and perhaps a mAb, especially for those with a history of failures in detoxification, or not responding to monotherapy. In patients with chronic migraine not overusing symptomatic medications, which is rare in our reality, a trial with a simple beta-blocker and a tricyclic antidepressant, both available and inexpensive in our country, would rate better than either of both in isolation.…”