Combining serum AFP and CEUS LI-RADS for better diagnostic performance in Chinese high-risk patients

Gong, Wushuang; Wu, Jiaqi; Wang, Hong; Jiang, Zhao-Peng; Wu, Ming; Wu, Chengwei; Xue, Weili; Ma, Rao; Zhou, Xian‐Li; Zhou, Huaqiang

doi:10.1007/s11547-023-01614-9

Cited by 4 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…836, respectively). The diagnostic e cacy has also been validated by other studies(15,(21)(22)(23). Consequently, it seems essential to reclassify HCCs in the LR-4 and LR-M category combined with AFP in both LR and HR groups to further improve the performance of CEUS LI-RADS in establishing an early and accurate diagnosis of HCC in a non-invasive manner.…”

mentioning

confidence: 82%

The Value of CEUS LI-RADS Combined with AFP in Early Diagnosis of Hepatocellular Carcinoma in Low- and High-Risk Patients

wu,

Chen,

Wei

et al. 2023

Preprint

View full text Add to dashboard Cite

Background We found that the incidence rate of hepatocellular carcinoma (HCC) has increased significantly in non-cirrhotic patients, with HCC being frequently overlooked or misdiagnosed. Contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) is known to have a high diagnostic value in high-risk HCC patients. Therefore, we aimed to compare the diagnostic value of CEUS LI-RADS for HCC between low- (LR) and high-risk (HR) patients, to confirm its value in LR patients. In addition, since CEUS LR-4 and LR-M categories contain a relatively high proportion of HCC, and serum alpha-fetoprotein (AFP) is the most used HCC biomarker, and the clinically valid, we attempted to further improve the early diagnostic value of CEUS LI-RADS for HCC in the LR and HR patients by combining CEUS LR-4 and LR-M categories with AFP. Methods We enrolled 189 HCC patients with LR and HR in a retrospective study. All lesions were confirmed histopathologically. Diagnostic performance of CEUS LI-RADS for HCC in these two patients was compared. In addition, we analyzed the value of CEUS LI-RADS as a valid method of establishing the early diagnosis for HCC in LR and HR patients by combining LR-4 and LR-M category with AFP. Results Through comparative analysis, we found that, due to the high proportion of HCC in CEUS LR-4 and LR-M categories in our cases, the specificity of CEUS LR-5 category for HCC in the HR group was 78.4%, whereas in the LR group it was 94.2%. Meanwhile, the sensitivity (63.2% vs 63.0%) and positive predictive value (PPV) (75.0% vs 88.7%) did not differ between the LR and HR groups (P = 0.299, P = 0.965). It is noteworthy that when we combined CEUS LR-4 and LR-M categories with AFP significantly improved the sensitivity and PPV by 21.0%, 5.0% in the LR group, and by 16.0%, 2.1% in the HR group (P = 0.836, P = 0.836, respectively). Conclusions The CEUS LR-5 category has real clinical value in diagnosing HCC in both LR and HR patients. The early diagnostic value of CEUS LI-RADS category for HCC patients was further increased when CEUS LR-4 and LR-M categories was combined with elevated AFP.

show abstract

mentioning

confidence: 82%

The Value of CEUS LI-RADS Combined with AFP in Early Diagnosis of Hepatocellular Carcinoma in Low- and High-Risk Patients

wu,

Chen,

Wei

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Microwave ablation followed by cTACE in 5-cm HCC lesions: does a single-session approach affect liver function?

Floridi,

Cacioppa,

Rossini

et al. 2024

Radiol med

View full text Add to dashboard Cite

Purpose Microwave ablation (MWA) and conventional transarterial chemoembolization (cTACE) are locoregional treatments commonly performed in very early, early and intermediate stages of hepatocellular carcinoma (HCC). Despite combined locoregional approaches have shown encouraging results in obtaining complete tumor necrosis, their application in a single session is poorly described. Our aim was to evaluate the safety and efficacy of single-session MWA and cTACE treatment in 5-cm HCCs and its influence on liver function. Materials and methods All 5-cm HCCs treated by MWA and cTACE performed in a single-session in our Interventional Radiology unit between January 2020 and December 2022 were retrospectively recorded and analyzed. Patients with poor or missing pre- and post-treatment imaging were excluded. Technical success, clinical success, and complications rate were examined as primary endpoints. Pre- and post-treatment liver function laboratory parameters were also evaluated. Results A total of 15 lesions (mean lesion diameter, 5.0 ± 1.4 cm) in 15 patients (11 men; mean age, 67.1 ± 8.9 years) were retrospectively evaluated. Technical and clinical success were 100% and 73%, respectively. Four (27%) cases of partial response and no cases of progressive or stable disease were recorded. AST and ALT values have found to be significantly higher in post-treatment laboratory tests. No other significant differences between pre- and post-treatment laboratory values were registered. AST and ALT pre- and post-treatment higher differences (ΔAST and ΔALT) were significantly associated with a lower clinical success rate. Conclusion MWA and cTACE single-session approach is safe and effective for 5-cm HCCs, without significant liver function impairment. A post-treatment increase in AST and ALT values may be a predictor for clinical failure.

show abstract

CEUS LI-RADS in Combination With the Serum Biomarker-Based ASAP Model Improves the Diagnostic Performance of HCC in High-Risk Patients

Wen,

Peng,

Liang

et al. 2024

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

Combining serum AFP and CEUS LI-RADS for better diagnostic performance in Chinese high-risk patients

Cited by 4 publications

References 37 publications

The Value of CEUS LI-RADS Combined with AFP in Early Diagnosis of Hepatocellular Carcinoma in Low- and High-Risk Patients

The Value of CEUS LI-RADS Combined with AFP in Early Diagnosis of Hepatocellular Carcinoma in Low- and High-Risk Patients

Microwave ablation followed by cTACE in 5-cm HCC lesions: does a single-session approach affect liver function?

CEUS LI-RADS in Combination With the Serum Biomarker-Based ASAP Model Improves the Diagnostic Performance of HCC in High-Risk Patients

Contact Info

Product

Resources

About